Depression as a microglial disease
Despite decades of intensive research, the biological mechanisms that causally underlie
depression are still unclear, and therefore the development of novel effective antidepressant …
depression are still unclear, and therefore the development of novel effective antidepressant …
Cortisol and major depressive disorder—translating findings from humans to animal models and back
Major depressive disorder (MDD) is a global problem for which current pharmacotherapies
are not completely effective. Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has …
are not completely effective. Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has …
Gene–stress–epigenetic regulation of FKBP5: clinical and translational implications
Stress responses and related outcomes vary markedly across individuals. Elucidating the
molecular underpinnings of this variability is of great relevance for developing individualized …
molecular underpinnings of this variability is of great relevance for developing individualized …
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Although the fact that genetic predisposition and environmental exposures interact to shape
development and function of the human brain and, ultimately, the risk of psychiatric …
development and function of the human brain and, ultimately, the risk of psychiatric …
Understanding the molecular mechanisms underpinning gene by environment interactions in psychiatric disorders: the FKBP5 model
Epidemiologic and genetic studies suggest common environmental and genetic risk factors
for a number of psychiatric disorders, including depression, bipolar disorder, and …
for a number of psychiatric disorders, including depression, bipolar disorder, and …
The role of DNA methylation in stress-related psychiatric disorders
Epigenetic modifications in response to traumatic experience and stress are emerging as
important factors in the long-term biological trajectories leading to stress-related psychiatric …
important factors in the long-term biological trajectories leading to stress-related psychiatric …
Gene–environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism
Psychiatric phenotypes are multifactorial and polygenic, resulting from the complex interplay
of genes and environmental factors that act cumulatively throughout an organism's lifetime …
of genes and environmental factors that act cumulatively throughout an organism's lifetime …
Stress induced microglial activation contributes to depression
B Li, W Yang, T Ge, Y Wang, R Cui - Pharmacological research, 2022 - Elsevier
Major depressive disorder (MDD) is a debilitating neuropsychological disorder, which has
caused serious health and socio-economic burdens worldwide. A growing body of evidence …
caused serious health and socio-economic burdens worldwide. A growing body of evidence …
Selective inhibitors of the FK506-binding protein 51 by induced fit
S Gaali, A Kirschner, S Cuboni, J Hartmann… - Nature chemical …, 2015 - nature.com
Abstract The FK506-binding protein 51 (FKBP51, encoded by the FKBP5 gene) is an
established risk factor for stress-related psychiatric disorders such as major depression …
established risk factor for stress-related psychiatric disorders such as major depression …
The specific role of reactive astrocytes in stroke
L Li, J Zhou, L Han, X Wu, Y Shi, W Cui… - Frontiers in Cellular …, 2022 - frontiersin.org
Astrocytes are essential in maintaining normal brain functions such as blood brain barrier
(BBB) homeostasis and synapse formation as the most abundant cell type in the central …
(BBB) homeostasis and synapse formation as the most abundant cell type in the central …