Chemistry of MRI contrast agents: current challenges and new frontiers

J Wahsner, EM Gale, A Rodríguez-Rodríguez… - Chemical …, 2018 - ACS Publications
Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

Chemical design and synthesis of functionalized probes for imaging and treating tumor hypoxia

J Liu, W Bu, J Shi - Chemical reviews, 2017 - ACS Publications
Hypoxia development in tumor is closely associated with its increased aggressiveness and
strong resistance to therapy, leading to the poor prognosis in several cancer types …

A molecular imaging primer: modalities, imaging agents, and applications

ML James, SS Gambhir - Physiological reviews, 2012 - journals.physiology.org
Molecular imaging is revolutionizing the way we study the inner workings of the human
body, diagnose diseases, approach drug design, and assess therapies. The field as a whole …

Chemical exchange saturation transfer (CEST): what is in a name and what isn't?

PCM Van Zijl, NN Yadav - Magnetic resonance in medicine, 2011 - Wiley Online Library
Chemical exchange saturation transfer (CEST) imaging is a relatively new magnetic
resonance imaging contrast approach in which exogenous or endogenous compounds …

Using lanthanide ions in molecular bioimaging

AJ Amoroso, SJA Pope - Chemical Society Reviews, 2015 - pubs.rsc.org
Trivalent lanthanide ions offer remarkable opportunities in the design of bioimaging agents:
this review presents an accessible discussion of their application in both optical and …

Inorganic nanoparticles for MRI contrast agents

HB Na, IC Song, T Hyeon - Advanced materials, 2009 - Wiley Online Library
Various inorganic nanoparticles have been used as magnetic resonance imaging (MRI)
contrast agents due to their unique properties, such as large surface area and efficient …

Metals in neurobiology: probing their chemistry and biology with molecular imaging

EL Que, DW Domaille, CJ Chang - Chemical reviews, 2008 - ACS Publications
The brain is a singular organ of unique biological complexity that serves as the command
center for cognitive and motor function. As such, this specialized system also possesses a …

Challenges for molecular magnetic resonance imaging

E Terreno, DD Castelli, A Viale, S Aime - Chemical reviews, 2010 - ACS Publications
Challenges for Molecular Magnetic Resonance Imaging | Chemical Reviews ACS ACS
Publications C&EN CAS Find my institution Log In Chemical Reviews ACS Publications. Most …

Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments

M Kim, J Gillen, BA Landman, J Zhou… - … in Medicine: An …, 2009 - Wiley Online Library
Chemical exchange saturation transfer (CEST) is a contrast mechanism that exploits
exchange‐based magnetization transfer (MT) between solute and water protons. CEST …

New technologies for human cancer imaging

JV Frangioni - Journal of clinical oncology, 2008 - ascopubs.org
Despite technical advances in many areas of diagnostic radiology, the detection and
imaging of human cancer remains poor. A meaningful impact on cancer screening, staging …