The global incidence of cardiac diseases is expected to increase in the coming years,
imposing a substantial socioeconomic burden on healthcare systems. Autophagy is a tightly …

The advent of human induced pluripotent stem cell (hiPSC) technology has revitalized the
efforts in the past decade to realize more fully the potential of human embryonic stem cells …

Congenital heart defects constitute the most common human birth defect, however
understanding of how these disorders originate is limited by our ability to model the human …

Chromatin architecture has been implicated in cell type-specific gene regulatory programs,
yet how chromatin remodels during development remains to be fully elucidated. Here, by …

It has been known for some time that atherosclerotic lesions preferentially develop in areas
exposed to low SS and are characterized by a proinflammatory, apoptotic, and senescent …

The discovery of induced pluripotent stem cells (iPSCs) a decade ago, which we are
celebrating in this issue of Cell, represents a landmark discovery in biomedical research …

Cardiac hypertrophy is a major risk factor for heart failure, and it has been shown that this
increase in size occurs at the level of the cardiac myocyte. Cardiac myocyte model systems …

Mitochondrial dysfunction is emerging as an important contributory factor to the
pathophysiology of lysosomal storage disorders (LSDs). The cause of mitochondrial …

Mutations in lysosomal-associated membrane protein 2 (LAMP-2) gene are associated with
Danon disease, which often leads to cardiomyopathy/heart failure through poorly defined …

Background Danon disease (DD) is a rare X-linked autophagic vacuolar myopathy,
characterized by high penetrance and severe cardiomyopathy. Because of its rarity, the …