During more than five decades, pyridinium oximes have been developed as therapeutic
agents used in the medical treatment of poisoning with organophosphorus compounds …

Organophosphate pesticides (OPPs; eg chlorpyrifos, diazinon, paraoxon) are a wide and
heterogeneous group of organophosphorus compounds. Their biological activity of …

The review summarizes research into the highly relevant topics of cholinesterase and
amyloid aggregation inhibitors connected to tacrine congeners, both of which are associated …

Unfunctionalized indoles can be directly converted into 3, 3′-spirocyclic indolenines and
indolines upon reaction with electrophilic dihalides in the presence of t-BuOK/BEt3. This …

This paper reviews the blood–brain barrier (BBB) penetration of newly developed pyridinium
aldoximes. Pyridinium aldoximes are highly charged hydrophilic compounds used in the …

Acetylcholinesterase (AChE) reactivators were developed for the treatment of
organophosphate intoxication. Standard care involves the use of anticonvulsants (eg …

Introduction. Organophosphorus pesticides and nerve agents are highly toxic to humans
and other living organisms, primarily because of their interaction with enzyme …

Acetylcholinesterase (AChE) reactivators are crucial antidotes to organophosphate
intoxication. A new series of 26 monooxime‐monocarbamoyl xylene‐linked bispyridinium …

Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate
intoxication. Fifteen new monooxime reactivators of acetylcholinesterase with a (E)-but-2 …

Four cyanobutadiene isomers of considerable interest to the organic chemistry, molecular
spectroscopy, and astrochemistry communities were synthesized in good yields and isolated …