Transcription factors of the NF-κB family regulate hundreds of genes in the context of
multiple important physiological and pathological processes. NF-κB activation depends on …

Since the discovery of interferon 50years ago a great deal of progress has been made in
understanding how interferons work and how and why they are induced. Key factors in …

Kaposi sarcoma herpesvirus (KSHV), taxonomical name human gammaherpesvirus 8, is a
phylogenetically old human virus that co-evolved with human populations, but is now only …

In response to invasion by microbial pathogens, host defense mechanisms get activated by
both the innate and adaptive arms of the immune responses. TNF (tumor necrosis factor) is a …

Highlights•KSHV/HHV8 causes three human diseases: Kaposi Sarcoma, Primary Effusion
Lymphoma and the plasma cell variant of Multicentric Castleman Disease.•These occur …

The nuclear factor (NF)-κB signaling pathway is pivotal for immune system function. Not
surprisingly, pathogenic microorganisms have developed strategies to subvert it. Two …

Nuclear factor κB (NF-κB) plays important roles in innate immune responses by regulating
the expression of a large number of target genes involved in the immune and inflammatory …

Upon viral infection, the major defense mounted by the host immune system is activation of
the interferon (IFN)-mediated antiviral pathway that is mediated by IFN regulatory factors …

Human herpesvirus-8 (HHV-8), also known as Kaposi sarcoma–associated herpesvirus
(KSHV), is etiologically linked to primary effusion lymphoma (PEL). At least 10 KSHV …

Co-infection with HIV-1 and Kaposi's sarcoma-associated herpesvirus (KSHV) is the cause
of aggressive AIDS-related Kaposi's sarcoma (AIDS-KS) characterized by abnormal …