Metastasis accounts for 90% of cancer-related deaths among the patients. The
transformation of epithelial cells into mesenchymal cells with molecular alterations can occur …

Gynecological and breast tumors are one of the main causes of cancer-related mortalities
among women. Despite recent advances in diagnostic and therapeutic methods, tumor …

Background Hypoxia is a frequent feature of solid tumors which significantly affects the
efficacy of treatments such as chemotherapy. In addition, exosomes from hypoxic cancer …

The mechanism by which transcription factor (TF) network instructs cell-type-specific
transcriptional programs to drive primitive endoderm (PrE) progenitors to commit to parietal …

Abstract FOXA1 (Forkhead Box A1) and FOXA2 (Forkhead Box A2) serve as pioneering
transcription factors that build gene expression capacity and play a central role in biological …

Organoids are in vitro 3D models that maintain their own tissue structure and function. They
largely overcome the limitations of traditional tumor models and have become a powerful …

The endometrium undergoes a series of precise monthly changes under the regulation of
dynamic levels of ovarian hormones that are characterized by repeated shedding and …

类器官作为一种新兴的三维细胞模型, 能够保留体内原始组织的组织学, 生理学及遗传学特征,
且具备培养时间短, 增殖效率高等优势, 已广泛应用于生命科学领域. 近年来 …

The female reproductive tract has its embryological origins in the paired Müllerian ducts and
their fusion to each other and the urogenital sinus. The Müllerian ducts give rise to the …

Endometrial cancer is the most common gynecologic malignancy in Canada with increasing
rates of both incidence and mortality. Historically, histopathological subtyping of endometrial …