WNT signalling has been studied primarily in developing embryos, in which cells respond to
WNTs in a context-dependent manner through changes in survival and proliferation, cell fate …

Organogenesis of the eye is a multistep process that starts with the formation of optic
vesicles followed by invagination of the distal domain of the vesicles and the overlying lens …

In the developing neural retina (NR), multipotent stem cells within the ciliary margin (CM)
contribute to de novo retinal tissue growth. We recently reported the ability of human …

Human and mouse embryonic stem cells (HESCs and MESCs, respectively) self-renew
indefinitely while maintaining the ability to generate all three germ-layer derivatives. Despite …

Adult zebrafish generate new neurons in the brain and retina throughout life. Growth-related
neurogenesis allows a vigorous regenerative response to damage, and fish can regenerate …

Background The persistence in adult teleost fish of retinal stem cells that exhibit all of the
features of true'adult stem cells'–self-renewal, multipotency, and the capacity to respond to …

Wnt signaling is activated by wounding and participates in every subsequent stage of the
healing process from the control of inflammation and programmed cell death, to the …

Eye development has been a paradigm for the study of organogenesis, from the
demonstration of lens induction through epithelial tissue morphogenesis, to neuronal …

Regeneration in the mammalian CNS is severely limited. Unlike in the chick, current models
hold that retinal neurons are never regenerated. Previously we demonstrated that, in the …

The retina in adult mammals, unlike those in lower vertebrates such as fish and amphibians,
is not known to support neurogenesis. However, when injured, the adult mammalian retina …