Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

Few metabolites can claim a more central and versatile role in cell metabolism than acetyl
coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the …

Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …

Short-chain fatty acids (SCFAs), particularly acetate, propionate and butyrate, are mainly
produced by anaerobic fermentation of gut microbes. SCFAs play an important role in …

Short-chain fatty acids (SCFAs), mainly including acetate, propionate, and butyrate, are
metabolites produced during the bacterial fermentation of dietary fiber in the intestinal tract …

Death is the inevitable fate of all living organisms, whether at the individual or cellular level.
For a long time, cell death was believed to be an undesirable but unavoidable final outcome …

Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …

Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Over the past few decades, substantial evidence has convincingly revealed the existence of
cancer stem cells (CSCs) as a minor subpopulation in cancers, contributing to an aberrantly …

Consumption of fructose has risen markedly in recent decades owing to the use of sucrose
and high-fructose corn syrup in beverages and processed foods, and this has contributed to …