Congenital lung malformations

F Pederiva, SS Rothenberg, N Hall… - Nature Reviews …, 2023 - nature.com
Congenital lung malformations (CLMs) are rare developmental anomalies of the lung,
including congenital pulmonary airway malformations (CPAM), bronchopulmonary …

Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia

E Lignelli, F Palumbo, D Myti… - American Journal of …, 2019 - journals.physiology.org
Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in
preterm infants. A key histopathological feature of BPD is stunted late lung development …

Cell response analysis in SARS-CoV-2 infected bronchial organoids

E Sano, T Suzuki, R Hashimoto, Y Itoh… - Communications …, 2022 - nature.com
The development of an in vitro cell model that can be used to study severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) research is expected. Here we conducted infection …

Resident interstitial lung fibroblasts and their role in alveolar stem cell niche development, homeostasis, injury, and regeneration

MG Ushakumary, M Riccetti… - Stem cells translational …, 2021 - academic.oup.com
Developing, regenerating, and repairing a lung all require interstitial resident fibroblasts
(iReFs) to direct the behavior of the epithelial stem cell niche. During lung development …

Hippo signaling pathway and respiratory diseases

W Tang, M Li, X Yangzhong, X Zhang, A Zu… - Cell Death …, 2022 - nature.com
The hippo signaling pathway is a highly conserved evolutionary signaling pathway that
plays an important role in regulating cell proliferation, organ size, tissue development, and …

Categorization of lung mesenchymal cells in development and fibrosis

X Liu, SC Rowan, J Liang, C Yao, G Huang, N Deng… - Iscience, 2021 - cell.com
Pulmonary mesenchymal cells are critical players in both the mouse and human during lung
development and disease states. They are increasingly recognized as highly …

Regeneration of tracheal neotissue in partially decellularized scaffolds

ZH Tan, S Dharmadhikari, L Liu, J Yu… - NPJ Regenerative …, 2023 - nature.com
Extensive tracheal injury or disease can be life-threatening but there is currently no standard
of care. Regenerative medicine offers a potential solution to long-segment tracheal defects …

The role of lung resident mesenchymal stromal cells in the pathogenesis and repair of chronic lung disease

DF Doherty, L Roets, AD Krasnodembskaya - Stem Cells, 2023 - academic.oup.com
Mesenchymal stromal/stem cells are multipotent adult cells that can be extracted from
numerous tissues, including the lungs. Lung-resident MSCs (LR-MSCs) are localized to …

Alveolar epithelial progenitor cells require Nkx2-1 to maintain progenitor-specific epigenomic state during lung homeostasis and regeneration

A Toth, P Kannan, J Snowball, M Kofron… - Nature …, 2023 - nature.com
Lung epithelial regeneration after acute injury requires coordination cellular coordination to
pattern the morphologically complex alveolar gas exchange surface. During adult lung …

Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K/Akt/Nrf2 signaling …

L Liu, Q Shi, K Wang, Y Qian, L Zhou, S Bellusci… - International …, 2022 - Elsevier
Particulate matter (PM) is a major environmental contaminant that causes and worsens
respiratory diseases. Fibroblast growth factor 10 (FGF10), a paracrine fibroblast growth …