Congenital lung malformations
F Pederiva, SS Rothenberg, N Hall… - Nature Reviews …, 2023 - nature.com
Congenital lung malformations (CLMs) are rare developmental anomalies of the lung,
including congenital pulmonary airway malformations (CPAM), bronchopulmonary …
including congenital pulmonary airway malformations (CPAM), bronchopulmonary …
Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia
E Lignelli, F Palumbo, D Myti… - American Journal of …, 2019 - journals.physiology.org
Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in
preterm infants. A key histopathological feature of BPD is stunted late lung development …
preterm infants. A key histopathological feature of BPD is stunted late lung development …
Cell response analysis in SARS-CoV-2 infected bronchial organoids
E Sano, T Suzuki, R Hashimoto, Y Itoh… - Communications …, 2022 - nature.com
The development of an in vitro cell model that can be used to study severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) research is expected. Here we conducted infection …
syndrome coronavirus 2 (SARS-CoV-2) research is expected. Here we conducted infection …
Resident interstitial lung fibroblasts and their role in alveolar stem cell niche development, homeostasis, injury, and regeneration
MG Ushakumary, M Riccetti… - Stem cells translational …, 2021 - academic.oup.com
Developing, regenerating, and repairing a lung all require interstitial resident fibroblasts
(iReFs) to direct the behavior of the epithelial stem cell niche. During lung development …
(iReFs) to direct the behavior of the epithelial stem cell niche. During lung development …
Hippo signaling pathway and respiratory diseases
W Tang, M Li, X Yangzhong, X Zhang, A Zu… - Cell Death …, 2022 - nature.com
The hippo signaling pathway is a highly conserved evolutionary signaling pathway that
plays an important role in regulating cell proliferation, organ size, tissue development, and …
plays an important role in regulating cell proliferation, organ size, tissue development, and …
Categorization of lung mesenchymal cells in development and fibrosis
Pulmonary mesenchymal cells are critical players in both the mouse and human during lung
development and disease states. They are increasingly recognized as highly …
development and disease states. They are increasingly recognized as highly …
Regeneration of tracheal neotissue in partially decellularized scaffolds
Extensive tracheal injury or disease can be life-threatening but there is currently no standard
of care. Regenerative medicine offers a potential solution to long-segment tracheal defects …
of care. Regenerative medicine offers a potential solution to long-segment tracheal defects …
The role of lung resident mesenchymal stromal cells in the pathogenesis and repair of chronic lung disease
DF Doherty, L Roets, AD Krasnodembskaya - Stem Cells, 2023 - academic.oup.com
Mesenchymal stromal/stem cells are multipotent adult cells that can be extracted from
numerous tissues, including the lungs. Lung-resident MSCs (LR-MSCs) are localized to …
numerous tissues, including the lungs. Lung-resident MSCs (LR-MSCs) are localized to …
Alveolar epithelial progenitor cells require Nkx2-1 to maintain progenitor-specific epigenomic state during lung homeostasis and regeneration
Lung epithelial regeneration after acute injury requires coordination cellular coordination to
pattern the morphologically complex alveolar gas exchange surface. During adult lung …
pattern the morphologically complex alveolar gas exchange surface. During adult lung …
Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K/Akt/Nrf2 signaling …
L Liu, Q Shi, K Wang, Y Qian, L Zhou, S Bellusci… - International …, 2022 - Elsevier
Particulate matter (PM) is a major environmental contaminant that causes and worsens
respiratory diseases. Fibroblast growth factor 10 (FGF10), a paracrine fibroblast growth …
respiratory diseases. Fibroblast growth factor 10 (FGF10), a paracrine fibroblast growth …