Transposable elements are mobile genetic units that exhibit broad diversity in their structure
and transposition mechanisms. Transposable elements occupy a large fraction of many …

Insulators are DNA sequence elements that prevent inappropriate interactions between
adjacent chromatin domains. One type of insulator establishes domains that separate …

Polycomb group (PcG) proteins maintain transcriptional repression during development,
likely by creating repressive chromatin states. The Extra Sex Combs (ESC) and Enhancer of …

An insulator is a DNA sequence that can act as a barrier to the influences of neighboring cis-
acting elements, preventing gene activation, for example, when located between an …

The anchor-away (AA) technique depletes the nucleus of Saccharomyces cerevisiae of a
protein of interest (the target) by conditional tethering to an abundant cytoplasmic protein …

Nucleotide-binding domain leucine-rich repeat receptors (NLRs) play important roles in the
innate immune systems of both plants and animals. Recent breakthroughs in NLR …

Eukaryotic genomes are organized into domains containing individual genes and gene
clusters that have distinct patterns of expression both during development and in …

Gene regulation is a complex process. Numerous factors appear to be required for the
accurate temporal and spatial regulation of each gene. Often these factors are assembled …

Abstract Interleukin-2 (IL-2)-deficient mice have cytoarchitectural hippocampal modifications
and impaired learning and memory ability reminiscent of Alzheimer's disease. IL-2 …

Insulators are DNA sequences that control the interactions among genomic regulatory
elements and act as chromatin boundaries. A thorough understanding of their location and …