MYC is one of the most important oncogenes in cancer. Indeed, MYC is upregulated in 50–
60% of all tumors. MYC overexpression can be achieved through a variety of mechanisms …

Super-enhancers (SEs) in a broad range of human cell types are large clusters of enhancers
with aberrant high levels of transcription factor binding, which are central to drive expression …

Background Chronic lymphocytic leukemia (CLL) results in increased susceptibility to
infections. T cell dysfunction is not associated with CLL in all patients; therefore, it is …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive leukemia that is most frequent
in children and is characterized by the presence of few chromosomal rearrangements and …

Proper subcellular localization is crucial for the functioning of biomacromolecules, including
proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the …

Abstract Interleukin-7 (IL-7) supports the growth and chemoresistance of T-cell acute
lymphoblastic leukemia (T-ALL), particularly the early T-cell precursor subtype (ETP-ALL) …

T-cell acute lymphoblastic leukemias (T-ALL) represent 15% of pediatric and 25% of adult
ALL. Since they have a particularly poor outcome in relapsed/refractory cases, identifying …

Bladder cancer is a common disease associated with high rates of morbidity and mortality.
Although immunotherapy approaches such as adoptive T-cell therapy and immune …

The polycomb repressive complex 2, with core components EZH2, SUZ12, and EED, is
responsible for writing histone 3 lysine 27 trimethylation histone marks associated with gene …

Genome-wide analysis of transcription factors and epigenomic features is instrumental to
shed light on DNA-templated regulatory processes such as transcription, cellular …