Surrogate end-point biomarkers (SEBs) have become widely used in short-term cancer
chemoprevention trials in place of cancer end points. This paper discusses criteria relevant …

Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-
inflammatory drugs (NSAIDs), particularly the highly selective cyclooxygenase (COX)-2 …

APOPTOSIS is a genetically encoded programme of cell death that can be activated under
physiological conditions1, 2 and may be an important safeguard against tumour …

Colorectal cancer (CRC) is among the top three cancer with higher incident and mortality
rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new …

THE interaction of cells with the extracellular matrix regulates cell shape, motility, growth,
survival, differentiation and gene expression, through integrin-mediated signal transduction1 …

Apoptosis is a form of programmed cell death that is essential for tissue homeostasis. De-
regulation of the balance between proliferation and apoptosis contributes to tumor initiation …

Although Apc is well characterized as a tumor-suppressor gene in the intestine, the precise
mechanism of this suppression remains to be defined. Using a novel inducible Ahcre …

Curcumin, derived from the rhizome of Curcuma longa L. and having both antioxidant and
anti-inflammatory properties, inhibits chemically induced carcinogenesis in the skin …

Nonstarch polysaccharides (NSPs) occur naturally in many foods. The physiochemical and
biological properties of these compounds correspond to dietary fiber. Nonstarch …

Deregulated inhibition of apoptosis (programmed cell death) may facilitate the insurgence of
neoplasia, but whether it also influences the outcome of common cancers has remained …