Surrogate end-point biomarkers (SEBs) have become widely used in short-term cancer
chemoprevention trials in place of cancer end points. This paper discusses criteria relevant …

Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-
inflammatory drugs (NSAIDs), particularly the highly selective cyclooxygenase (COX)-2 …

APOPTOSIS is a genetically encoded programme of cell death that can be activated under
physiological conditions1, 2 and may be an important safeguard against tumour …

Although Apc is well characterized as a tumor-suppressor gene in the intestine, the precise
mechanism of this suppression remains to be defined. Using a novel inducible Ahcre …

THE interaction of cells with the extracellular matrix regulates cell shape, motility, growth,
survival, differentiation and gene expression, through integrin-mediated signal transduction1 …

Curcumin, derived from the rhizome of Curcuma longa L. and having both antioxidant and
anti-inflammatory properties, inhibits chemically induced carcinogenesis in the skin …

Nonstarch polysaccharides (NSPs) occur naturally in many foods. The physiochemical and
biological properties of these compounds correspond to dietary fiber. Nonstarch …

Colorectal cancer (CRC) is among the top three cancer with higher incident and mortality
rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new …

Deregulated inhibition of apoptosis (programmed cell death) may facilitate the insurgence of
neoplasia, but whether it also influences the outcome of common cancers has remained …

Aberrant inhibition of programmed cell death (apoptosis) prevents normal homeostasis and
promotes tissue tumorigenesis, but whether it also influences the outcome of common …