Hereditary fructose intolerance (HFI, OMIM 22960), caused by catalytic deficiency of
aldolase B (fructose-1, 6-bisphosphate aldolase, EC 4.1. 2.13), is a recessively inherited …

A number of significant biocatalysts have been investigated over the past year to improve
accessibility, functional knowledge and use in developing synthetic applications. In …

Constructing different protein nanostructures with high-order discrete architectures by using
one single building block remains a challenge. Here, we present a simple, effective disulfide …

Dihydrodipicolinate synthase (DHDPS) is an essential enzyme in (S)-lysine biosynthesis
and an important antibiotic target. All X-ray crystal structures solved to date reveal a …

The structure of the glycolytic enzyme class I fructose-1, 6-bisphosphate aldolase from the
human malaria parasite Plasmodium falciparum has been determined by X-ray …

Triosephosphate isomerase (TIM) is a very stable dimer. In order to understand better the
importance of dimerization for stability and catalytic activity, we have constructed a …

Protein tyrosine nitration increases in vivo as a result of oxidative stress and is elevated in
numerous inflammatory-associated diseases. Mammalian fructose-1, 6-bisphosphate …

The glycolytic enzyme aldolase is concentrated in a domain around stress fibers in living
Swiss 3T3 cells, but the mechanism by which aldolase is localized has not been revealed …

The X-ray crystallographic structure of the human liver isozyme of fructose-1, 6-
bisphosphate aldolase has been determined by molecular replacement using a tetramer of …

Summary α/β-Knotted proteins are an extraordinary example of biological self-assembly;
they contain a deep topological trefoil knot formed by the backbone polypeptide chain …