Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …

Mosquitoes bring global health problems by transmitting parasites and viruses such as
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …

Abstract Cas9/gRNA-mediated gene-drive systems have advanced development of genetic
technologies for controlling vector-borne pathogen transmission. These technologies …

Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …

Population-scale genome modification can alter the composition or fate of wild populations.
Synthetic gene drives provide one set of tools, but their use is complicated by scientific …

Mosquito-borne diseases, such as dengue and malaria, pose a significant burden to global
health. Current control strategies with insecticides are only moderately effective. Scalable …

Genetic control strategies such as the sterile insect technique have successfully fought
insect pests worldwide. The CRISPR (clustered regularly interspaced short palindromic …

Gene drive elements promote the spread of linked traits and can be used to change the
composition or fate of wild populations. Cleave and Rescue (ClvR) drive elements sit at a …

Synthetic gene drive constructs could, in principle, provide the basis for highly efficient
interventions to control disease vectors and other pest species. This efficiency derives in part …

Synthetic gene drive (GD) systems constitute a form of novel invasive environmental
biotechnology with far-reaching consequences beyond those of other known genetically …