Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …

Mosquitoes bring global health problems by transmitting parasites and viruses such as
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …

Abstract Cas9/gRNA-mediated gene-drive systems have advanced development of genetic
technologies for controlling vector-borne pathogen transmission. These technologies …

Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …

Synthetic gene drive constructs could, in principle, provide the basis for highly efficient
interventions to control disease vectors and other pest species. This efficiency derives in part …

Genetic control strategies such as the sterile insect technique have successfully fought
insect pests worldwide. The CRISPR (clustered regularly interspaced short palindromic …

Wolbachia are maternally-inherited bacteria, which can spread rapidly in populations by
manipulating reproduction. cifA and cifB are genes found in Wolbachia phage that are …

The ability to engineer gene drives (genetic elements that bias their own inheritance) has
sparked enthusiasm and concerns. Engineered gene drives could potentially be used to …

Homing-based gene drives, engineered using CRISPR/Cas9, have been proposed to
spread desirable genes throughout populations. However, invasion of such drives can be …

Gene drives for mosquito population modification are novel tools for malaria control.
Strategies to safely test antimalarial effectors in the field are required. Here, we modified the …