Aspergillus fumigatus and Aspergillosis in 2019

JP Latgé, G Chamilos - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

The high osmolarity glycerol (HOG) pathway in fungi

H Yaakoub, NS Sanchez, L Ongay-Larios… - Critical Reviews in …, 2022 - Taylor & Francis
While fungi are widely occupying nature, many species are responsible for devastating
mycosis in humans. Such niche diversity explains how quick fungal adaptation is necessary …

Nature of β-1, 3-glucan-exposing features on Candida albicans cell wall and their modulation

LJ de Assis, JM Bain, C Liddle, I Leaves, C Hacker… - MBio, 2022 - Am Soc Microbiol
Candida albicans exists as a commensal of mucosal surfaces and the gastrointestinal tract
without causing pathology. However, this fungus is also a common cause of mucosal and …

Carbon catabolite repression in filamentous fungi is regulated by phosphorylation of the transcription factor CreA

LJ de Assis, LP Silva, O Bayram, P Dowling… - MBio, 2021 - Am Soc Microbiol
Filamentous fungi of the genus Aspergillus are of particular interest for biotechnological
applications due to their natural capacity to secrete carbohydrate-active enzymes (CAZy) …

Stress-activated protein kinases in human fungal pathogens

AM Day, J Quinn - Frontiers in cellular and infection microbiology, 2019 - frontiersin.org
The ability of fungal pathogens to survive hostile environments within the host depends on
rapid and robust stress responses. Stress-activated protein kinase (SAPK) pathways are …

Comprehensively dissecting the hub regulation of PkaC on high‐productivity and pellet macromorphology in citric acid producing Aspergillus niger

X Zheng, TC Cairns, X Ni, L Zhang, H Zhai… - Microbial …, 2022 - Wiley Online Library
Aspergillus niger, an important industrial workhorse for citric acid production, is
characterized by polar hyphal growth with complex pelleted, clumped or dispersed …

The Transcription Factor SomA Synchronously Regulates Biofilm Formation and Cell Wall Homeostasis in Aspergillus fumigatus

Y Chen, F Le Mauff, Y Wang, R Lu, DC Sheppard, L Lu… - MBio, 2020 - Am Soc Microbiol
Polysaccharides are key components of both the fungal cell wall and biofilm matrix. Despite
having distinct assembly and regulation pathways, matrix exopolysaccharide and cell wall …

Anticipatory stress responses and immune evasion in fungal pathogens

A Pradhan, Q Ma, LJ de Assis, I Leaves… - Trends in …, 2021 - cell.com
In certain niches, microbes encounter environmental challenges that are temporally linked.
In such cases, microbial fitness is enhanced by the evolution of anticipatory responses …

How environmental fungi cause a range of clinical outcomes in susceptible hosts

ST Denham, MA Wambaugh, JCS Brown - Journal of molecular biology, 2019 - Elsevier
Environmental fungi are globally ubiquitous and human exposure is near universal.
However, relatively few fungal species are capable of infecting humans, and among fungi …

The Aspergillus fumigatus phosphoproteome reveals roles of high-osmolarity glycerol mitogen-activated protein kinases in promoting cell wall damage and …

EC Mattos, LP Silva, C Valero, PA de Castro… - MBio, 2020 - Am Soc Microbiol
The filamentous fungus Aspergillus fumigatus can cause a distinct set of clinical disorders in
humans. Invasive aspergillosis (IA) is the most common life-threatening fungal disease of …