The last decade of microbiome research has highlighted its fundamental role in systemic
immune and metabolic homeostasis. The microbiome plays a prominent role during …

Asthma is the most common chronic disease within the paediatric population. Although it is
multifactorial, its onset may be linked to early-life exposures with subsequent impact on …

Antibiotic use in early life disrupts microbial colonization and increases the risk of
developing allergies and asthma. We report that mice given antibiotics in early life (EL-Abx) …

The role of the microbiome in asthma is highlighted, considering its influence on immune
responses and its connection to alterations in asthmatic patients. In this context, we review …

Asthma is one of the common chronic respiratory diseases in children, which poses a
serious threat to children's quality of life. Respiratory infection is a risk factor for asthma …

Breastfeeding and microbial colonization during infancy occur within a critical time window
for development, and both are thought to influence the risk of respiratory illness. However …

Background While dysregulated sphingolipid metabolism has been associated with risk of
childhood asthma, the specific sphingolipid classes and/or mechanisms driving this …

Background While several traditional observational studies have suggested associations
between gut microbiota and asthma, these studies are limited by factors such as participant …

Objectives Recent studies suggest immunophenotypes may play a role in asthma, but their
causal relationship has not been thoroughly examined. Methods We used single nucleotide …

This is an exciting time to be conducting asthma research. The recent development of
targeted asthma biologics has validated the power of basic research to discover new …