Histotripsy: a method for mechanical tissue ablation with ultrasound

Z Xu, TD Khokhlova, CS Cho… - Annual Review of …, 2024 - annualreviews.org
Histotripsy is a relatively new therapeutic ultrasound technology to mechanically liquefy
tissue into subcellular debris using high-amplitude focused ultrasound pulses. In contrast to …

Insights from in vivo preclinical cancer studies with histotripsy

T Worlikar, T Hall, M Zhang… - International Journal …, 2024 - Taylor & Francis
Histotripsy is the first noninvasive, non-ionizing, and non-thermal ablation technique that
mechanically fractionates target tissue into acellular homogenate via controlled acoustic …

Histotripsy for the Treatment of Cholangiocarcinoma Liver Tumors: In Vivo Feasibility and Ex Vivo Dosimetry Study

A Hendricks-Wenger, P Weber, A Simon… - IEEE transactions on …, 2021 - ieeexplore.ieee.org
Histotripsy is a noninvasive, nonionizing, and nonthermal focused ultrasound ablation
method that is currently being developed for the treatment of liver cancer. Promisingly …

An X-ray C-arm guided automatic targeting system for histotripsy

MG Wagner, S Periyasamy, AZ Kutlu… - IEEE Transactions …, 2022 - ieeexplore.ieee.org
Objective: Histotripsy is an emerging noninvasive, nonionizing and nonthermal focal cancer
therapy that is highly precise and can create a treatment zone of virtually any size and …

Soft tissue aberration correction for histotripsy using acoustic emissions from cavitation cloud nucleation and collapse

E Yeats, N Lu, JR Sukovich, Z Xu, TL Hall - Ultrasound in medicine & …, 2023 - Elsevier
Objective Phase aberration from soft tissue limits the efficacy of histotripsy, a therapeutic
ultrasound technique based on acoustic cavitation. Previous work has shown that the …

[HTML][HTML] Advanced techniques in the percutaneous ablation of liver tumours

TCH Hui, J Kwan, U Pua - Diagnostics, 2021 - mdpi.com
Percutaneous ablation is an accepted treatment modality for primary hepatocellular
carcinoma (HCC) and liver metastases. The goal of curative ablation is to cause the necrosis …

Hepatic and renal histotripsy in an anticoagulated porcine model

SC Mauch, AM Zlevor, EA Knott, AB Couillard… - Journal of Vascular and …, 2023 - Elsevier
Purpose To determine the risk of mechanical vessel wall damage resulting in hemorrhage
during and after hepatic and renal histotripsy in an anticoagulated in vivo porcine model …

Clinical translation of abdominal histotripsy: a review of preclinical studies in large animal models

KL Falk, PF Laeseke, MA Kisting… - International Journal …, 2023 - Taylor & Francis
Histotripsy is an emerging noninvasive, non-thermal, and non-ionizing focused ultrasound
(US) therapy that can be used to destroy targeted tissue. Histotripsy has evolved from early …

A comparison study of microwave ablation vs. histotripsy for focal liver treatments in a swine model

EA Knott, AM Zlevor, JL Hinshaw, PF Laeseke… - European …, 2023 - Springer
Objective To compare the acute and chronic safety and treatment effects of non-invasive
hepatic histotripsy vs. percutaneous microwave (MW) ablation in a healthy porcine model …

A comparison of histotripsy and percutaneous cryoablation in a chronic healthy swine kidney model

AB Couillard, AM Zlevor, TJ Ziemlewicz… - Journal of Vascular and …, 2023 - Elsevier
Purpose To compare the safety and efficacy of histotripsy with cryoablation in a chronic
human-scale normal porcine kidney model. Materials and Methods Eighteen female …