Spectroscopic studies, DFT calculations, cytotoxicity activity, and docking stimulation of novel metal complexes of Schiff base ligand of isonicotinohydrazide derivative

NH Mahmoud, GH Elsayed… - Applied …, 2022 - Wiley Online Library
In this elucidation, the reactivity of isonicotinohydrazide derivative (3)(L) was reacted with
the nitrate salts of Cr (III), Fe (III), Co (II), Ni (II), Cu (II), and Zn (II) to afford the corresponding …

Synthesis, anti‐proliferative activities, docking studies, and computational calculations of novel isonicotinic mixed complexes

AM Fahim, HS Magar… - Applied Organometallic …, 2022 - Wiley Online Library
In this investigation, we studied the mixing of two ligands, isonicotinohydrazide (L1) and 3‐
hydroxyisonicotinic acid (L2), with different metal ions to afford the corresponding stable …

Anticancer activity, DNA binding, and photodynamic properties of a N∧ C∧ N-coordinated Pt (II) complex

S Scoditti, E Dabbish, N Russo, G Mazzone… - Inorganic …, 2021 - ACS Publications
In the effort to discover new targets and improve the therapeutic efficacy of metal-containing
anticancer compounds, transition metal complexes that can elicit cytotoxicity when irradiated …

Computational Assessment of a Dual-Action Ru (II)-Based Complex: Photosensitizer in Photodynamic Therapy and Intercalating Agent for Inducing DNA Damage

F Ponte, S Scoditti, P Barretta, G Mazzone - Inorganic Chemistry, 2023 - ACS Publications
A combined quantum-mechanical and classical molecular dynamics study of a recent Ru (II)
complex with potential dual anticancer action is reported here. The main basis for the …

Intercalation ability of novel monofunctional platinum anticancer drugs: a key step in their biological action

D Veclani, M Tolazzi, JP Cerón-Carrasco… - Journal of Chemical …, 2021 - ACS Publications
Phenanthriplatin (PtPPH) is a monovalent platinum (II)-based complex with a large
cytotoxicity against cancer cells. Although the aqua-activated drug has been assumed to be …

Efficient synthesis of new 6-arylphenanthridines based on microwave-assisted Suzuki–Miyaura cross-coupling and Pictet–Spengler dehydrogenative cyclization in a …

AF Villamizar-Mogotocoro, SM Bonilla-Castañeda… - Green …, 2022 - pubs.rsc.org
An ecofriendly, efficient method for the synthesis of new pharmacologically active 6-
arylphenanthridines has been developed for the first time. This method involves consecutive …

[HTML][HTML] Computational Studies of the Photogeneration from Dihydrosanguinarine and the Probable Cytotoxicity Mechanism of Sanguinarine

S Scoditti, S Bruno, E Sicilia, G Mazzone - Applied Sciences, 2022 - mdpi.com
A computational investigation of the mechanism of dihydrosanguinarine (DHSAN)
photoactivation and its conversion into the active drug sanguinarine (SAN) is here reported …

Simple and efficient microwave-assisted synthesis of new N-biphenyl cinnamamides/3-arylpropanamides and C6-substituted phenanthridines

AF Villamizar–Mogotocoro, VV Kouznetsov - Tetrahedron Letters, 2023 - Elsevier
We hereby report an efficient method for the preparation of a series of new N-biphenyl-
cinnamamides/3-arylpropanamides through a three–step, clean, good–yielding …

One‐and Two‐Electron Reductions in MiniSOG and their Implication in Catalysis

O Azpitarte, A Zudaire, J Uranga, X Lopez… - …, 2023 - Wiley Online Library
The unconventional bioorthogonal catalytic activation of anticancer metal complexes by
flavin and flavoproteins photocatalysis has been reported recently. The reactivity is based on …

[PDF][PDF] Assessment of Available AMBER Force Fields to Model DNA-Ligand Interactions

M Misra, AK Yadav - Biointerface Res. Appl. Chem., 2022 - researchgate.net
Deoxyribonucleic acid, commonly referred to as DNA is a promising cellular target for
anticancer agents. The interaction of drugs with nucleic acid is an essential feature of …