Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

The homeobox (HOX) genes encoding an evolutionarily highly conserved family of
homeodomain-containing transcriptional factors are essential for embryogenesis and …

Cardiomyocyte (CM) replacement is very slow in adult mammalian hearts, preventing
regeneration of damaged myocardium. By contrast, fetal hearts display considerable …

Background: The regenerative capacity of the heart after myocardial infarction is limited. Our
previous study showed that ectopic introduction of 4 cell cycle factors (4F; CDK1 [cyclin …

BACKGROUND: Experiments in mammalian models of cardiac injury suggest that the
cardiomyocyte-specific overexpression of CCND2 (cyclin D2, in humans) improves recovery …

In the past few decades, cardiac regeneration has been the central target for restoring the
injured heart. In mammals, cardiomyocytes are terminally differentiated and rarely divide …

Circular RNAs take crucial roles in several pathophysiological processes. The regulatory
role and its underlying mechanisms of circ-ZNF609 in the heart remains largely unknown …

With the high morbidity and mortality rates, cardiovascular diseases have become one of the
most concerning diseases worldwide. The heart of adult mammals can hardly regenerate …

Heart injury such as myocardial infarction leads to cardiomyocyte loss, fibrotic tissue
deposition, and scar formation. These changes reduce cardiac contractility, resulting in heart …

During cardiac development and morphogenesis, cardiac progenitor cells differentiate into
cardiomyocytes that expand in number and size to generate the fully formed heart. Much is …