The most commonly used treatment for Parkinson's disease (PD) is levodopa, prescribed in
conjunction with carbidopa. Virtually all patients with PD undergo dopamine replacement …

Neurodegenerative diseases (NDs) are characterized by progressive degeneration and
necrosis of neurons, including Alzheimer's disease (AD), Parkinson's disease (PD) …

Monoterpene indole alkaloids (MIAs) are a structurally diverse family of specialized
metabolites mainly produced in Gentianales to cope with environmental challenges. Due to …

Natural antioxidants derived from plants have been proven to have significant inhibitory
effects on the free radicals of living organisms during actively metabolization. Excessive …

Neurodegenerative diseases (NDs) are a widespread and serious global public health
burden, particularly among the older population. At present, effective therapies do not exist …

Parkinson's disease (PD) is one of the progressive neurological diseases which affect
around 10 million population worldwide. The clinical manifestation of motor symptoms in PD …

Parkinson's disease (PD) is a common neurodegenerative disorder of middle-aged and
elderly people, clinically characterized by resting tremor, myotonia, reduced movement, and …

KW-6356 is a novel adenosine A 2A receptor antagonist/inverse agonist that not only blocks
binding of adenosine to adenosine A 2A receptor but also inhibits the constitutive activity of …

Vestigial dopaminergic cells in PD have selectivity for a sub-class of hypersensitive neurons
with the nigrostriatal dopamine (DA) tract. DA is modulated in pre-synaptic nerve terminals to …

Parkinson's disease (PD), one of the most common neurological diseases worldwide, is
mainly characterized neuropathologically by the dopaminergic neurodegeneration in the …