Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …

Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …

Only female insects transmit diseases such as malaria, dengue and Zika; therefore, control
methods that bias the sex ratio of insect offspring have long been sought. Genetic elements …

CRISPR-based gene-drives targeting the gene doublesex in the malaria vector Anopheles
gambiae effectively suppressed the reproductive capability of mosquito populations reared …

Aedes mosquito-transmitted diseases, such as dengue, Zika and chikungunya, are
becoming major global health emergencies while old threats, such as yellow fever, are re …

Genetic-based methods offer environmentally friendly species-specific approaches for
control of insect pests. One method, CRISPR homing gene drive that target genes essential …

Homing-based gene drives use a germline source of nuclease to copy themselves at
specific target sites in a genome and bias their inheritance. Such gene drives can be …

Mosquitoes bring global health problems by transmitting parasites and viruses such as
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …

Discovered as a bacterial adaptive immune system, CRISPR/Cas9 (clustered, regularly
interspaced, short palindromic repeat/CRISPR associated) is being developed as an …

Since the implementation of Roll Back Malaria, the widespread use of insecticide-treated
nets (ITNs) and indoor residual spraying (IRS) is thought to have played a major part in the …