[HTML][HTML] Biomedical applications of microfluidic devices: a review
Both passive and active microfluidic chips are used in many biomedical and chemical
applications to support fluid mixing, particle manipulations, and signal detection. Passive …
applications to support fluid mixing, particle manipulations, and signal detection. Passive …
[HTML][HTML] Antifibrotic therapy in nonalcoholic steatohepatitis: time for a human-centric approach
Nonalcoholic steatohepatitis (NASH) might soon become the leading cause of end-stage
liver disease and indication for liver transplantation worldwide. Fibrosis severity is the only …
liver disease and indication for liver transplantation worldwide. Fibrosis severity is the only …
[HTML][HTML] iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies
VEJM Palasantzas, I Tamargo-Rubio, K Le, J Slager… - Trends in Genetics, 2023 - cell.com
Genome-wide association studies (GWAS) have now correlated hundreds of genetic
variants with complex genetic diseases and drug efficacy. Functional characterization of …
variants with complex genetic diseases and drug efficacy. Functional characterization of …
[HTML][HTML] Recent developments in microfluidic technology for synthesis and toxicity-efficiency studies of biomedical nanomaterials
Microfluidic technology is a relatively new field among the various conventional bulk
techniques employed for nanomaterial synthesis. Nanoparticles (NPs) produced using such …
techniques employed for nanomaterial synthesis. Nanoparticles (NPs) produced using such …
[HTML][HTML] In vitro models for non-alcoholic fatty liver disease: Emerging platforms and their applications
MJ Ramos, L Bandiera, F Menolascina, JA Fallowfield - Iscience, 2022 - cell.com
Non-alcoholic fatty liver disease (NAFLD) represents a global healthcare challenge,
affecting 1 in 4 adults, and death rates are predicted to rise inexorably. The progressive form …
affecting 1 in 4 adults, and death rates are predicted to rise inexorably. The progressive form …
Tailoring biomaterials for biomimetic organs-on-chips
Organs-on-chips are microengineered microfluidic living cell culture devices with
continuously perfused chambers penetrating to cells. By mimicking the biological features of …
continuously perfused chambers penetrating to cells. By mimicking the biological features of …
[HTML][HTML] Microfluidic organ-on-a-chip devices for liver disease modeling in vitro
P Kanabekova, A Kadyrova, G Kulsharova - Micromachines, 2022 - mdpi.com
Mortality from liver disease conditions continues to be very high. As liver diseases manifest
and progress silently, prompt measures after diagnosis are essential in the treatment of …
and progress silently, prompt measures after diagnosis are essential in the treatment of …
[HTML][HTML] State-of-the-art liver disease research using liver-on-a-chip
S Deguchi, K Takayama - Inflammation and Regeneration, 2022 - Springer
To understand disease pathophysiologies, models that recapitulate human functions are
necessary. In vitro models that consist of human cells are preferred to ones using animal …
necessary. In vitro models that consist of human cells are preferred to ones using animal …
[HTML][HTML] In vitro models for the study of liver biology and diseases: advances and limitations
In vitro models of liver (patho) physiology, new technologies, and experimental approaches
are progressing rapidly. Based on cell lines, induced pluripotent stem cells or primary cells …
are progressing rapidly. Based on cell lines, induced pluripotent stem cells or primary cells …
[HTML][HTML] Liver spheroids on chips as emerging platforms for drug screening
D Huang, X Zhang, X Fu, Y Zu, W Sun, Y Zhao - Engineered Regeneration, 2021 - Elsevier
Liver plays a critical role in drug metabolism and nowadays multi-cellular culture systems
aiming at imitating liver-specific morphology and functionality are advancing robustly …
aiming at imitating liver-specific morphology and functionality are advancing robustly …