Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

Drug metabolism as a discipline plays an important role in drug discovery and development
and the effects of drug metabolism on pharmacokinetics (PK), pharmacodynamics (PD), and …

Cytochrome P450 (P450) enzymes are important in the metabolism of drugs, steroids, fat-
soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Their catalytic …

The cytochromes P450 constitute a large family of cysteinato-heme enzymes, 1-9 are
present in all forms of life (plants, bacteria, and mammals), and play a key role in the …

Dioxygen (O2) serves two essential functions in aerobic life. It is both a terminal electron
acceptor and a biosynthetic reagent. It is this latter role for dioxygen that will be the focus of …

The title to a seminar presentation by IC Gunsalus in 1973 was “Oxygen: An essential toxin”,
referring to the complex role that atmospheric dioxygen has in biology. The relatively simple …

Cytochrome P450 (P450) enzymes catalyze a variety of reactions and convert chemicals to
potentially reactive products as well as make compounds less toxic. Most of the P450 …

More than 90% of cases of congenital adrenal hyperplasia (CAH, the inherited inability to
synthesize cortisol) are caused by 21-hydroxylase deficiency. Females with severe, classic …

While rust is an unwanted oxidation reaction, there are also many other useful oxidation
reactions that are extremely important and number among the most commonly used …

Natural products have played a prominent role in the history of organic chemistry, and they
continue to be important as drugs, biological probes, and targets of study for synthetic and …