[HTML][HTML] Targeting voltage-dependent calcium channels with pregabalin exerts a direct neuroprotective effect in an animal model of multiple sclerosis

P Hundehege, J Fernandez-Orth, P Römer, T Ruck… - Neurosignals, 2019 - karger.com
Background/Aims: Multiple sclerosis (MS) is a prototypical autoimmune central nervous
system (CNS) disease. Particularly progressive forms of MS (PMS) show significant …

Harnessing cortical plasticity via gabapentinoid administration promotes recovery after stroke

A Tedeschi, MJE Larson, A Zouridakis, L Mo, A Bordbar… - Brain, 2022 - academic.oup.com
Stroke causes devastating sensory-motor deficits and long-term disability due to disruption
of descending motor pathways. Restoration of these functions enables independent living …

Treatment of pain in rabbits

S Ozawa, A Cenani, DSMG Lv - Veterinary Clinics: Exotic …, 2023 - vetexotic.theclinics.com
According to the American Veterinary Medical Association (AVMA) demographics, rabbits
are the third most common companion mammal in the United States. 1 In addition, rabbits …

The value of signal peptide‐CUB‐EGF domain‐containing protein 1 and oxidative stress parameters in the diagnosis of acute mesenteric ischemia

S Turkmen, S Mentese, A Mentese… - Academic …, 2013 - Wiley Online Library
Objectives This study investigated the diagnostic value of signal peptide‐CUB‐EGF domain‐
containing protein 1 (SCUBE‐1) and other oxidative stress parameters in the early diagnosis …

[HTML][HTML] Early administration of gabapentinoids improves motor recovery after human spinal cord injury

FM Warner, JJ Cragg, CR Jutzeler, F Röhrich… - Cell reports, 2017 - cell.com
The anticonvulsant pregabalin promotes neural regeneration in a mouse model of spinal
cord injury (SCI). We have also previously observed that anticonvulsants improve motor …

Effects of Pain and Pain Management on Motor Recovery of Spinal Cord–Injured Patients: A Longitudinal Study

JJ Cragg, J Haefeli, CR Jutzeler… - … and neural repair, 2016 - journals.sagepub.com
Background. Approximately 60% of patients suffering from acute spinal cord injury (SCI)
develop pain within days to weeks after injury, which ultimately persists into chronic stages …

Gabapentin decreases epileptiform discharges in a chronic model of neocortical trauma

H Li, KD Graber, S Jin, W McDonald, BA Barres… - Neurobiology of …, 2012 - Elsevier
Gabapentin (GBP) is an anticonvulsant that acts at the α2δ-1 submit of the L-type calcium
channel. It is recently reported that GBP is a potent inhibitor of thrombospondin (TSP) …

α2δ-1 signaling drives cell death, synaptogenesis, circuit reorganization, and gabapentin-mediated neuroprotection in a model of insult-induced cortical malformation

LA Lau, F Noubary, D Wang, CG Dulla - ENeuro, 2017 - eneuro.org
Developmental cortical malformations (DCMs) result from pre-and perinatal insults, as well
as genetic mutations. Hypoxia, viral infection, and traumatic injury are the most common …

Effects of curcumin on acute spinal cord ischemia-reperfusion injury in rabbits

G Kurt, Z Yildirim, B Cemil, E Celtikci… - Journal of Neurosurgery …, 2014 - thejns.org
Object The object of this study was to conduct a prospective, randomized, laboratory
investigation of the neuroprotective effects of curcumin functionally, biochemically, and …

Behavioral and physiologic effects of a single dose of oral gabapentin in rabbits (Oryctolagus cuniculus)

RE Conway, M Burton, K Mama, S Rao… - Topics in Companion …, 2023 - Elsevier
Stress in rabbits (Oryctolagus cuniculus) may influence veterinarians' ability to assess their
health and can lead to complications such as gastrointestinal hypomotility and poor …