[HTML][HTML] Brain-derived neurotrophic factor, depression, and physical activity: making the neuroplastic connection

C Phillips - Neural plasticity, 2017 - hindawi.com
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival,
growth, and maintenance of neurons in key brain circuits involved in emotional and …

Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers

C Reitz, R Mayeux - Biochemical pharmacology, 2014 - Elsevier
The global prevalence of dementia is as high as 24 million, and has been predicted to
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …

Mini‐Mental State Examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive impairment (MCI)

I Arevalo‐Rodriguez, N Smailagic… - Cochrane database …, 2015 - cochranelibrary.com
Background Dementia is a progressive global cognitive impairment syndrome. In 2010,
more than 35 million people worldwide were estimated to be living with dementia. Some …

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

SW Min, X Chen, TE Tracy, Y Li, Y Zhou, C Wang… - Nature medicine, 2015 - nature.com
Tauopathies, including frontotemporal dementia (FTD) and Alzheimer's disease (AD), are
neurodegenerative diseases in which tau fibrils accumulate. Recent evidence supports …

[HTML][HTML] Lifestyle modulators of neuroplasticity: how physical activity, mental engagement, and diet promote cognitive health during aging

C Phillips - Neural plasticity, 2017 - hindawi.com
The number of the elderly across the globe will approximate 2.1 billion by 2050. Juxtaposed
against this burgeoning segment of the population is evidence that nonpathological aging is …

Alzheimer disease

LG Apostolova - Continuum: Lifelong Learning in Neurology, 2016 - journals.lww.com
Abstract Purpose of Review: This article discusses the recent advances in the diagnosis and
treatment of Alzheimer disease (AD). Recent Findings: In recent years, significant advances …

Epidemiology of Alzheimer disease

C Reitz, C Brayne, R Mayeux - Nature Reviews Neurology, 2011 - nature.com
The global prevalence of dementia is estimated to be as high as 24 million, and is predicted
to double every 20 years through to 2040, leading to a costly burden of disease. Alzheimer …

Revising the definition of Alzheimer's disease: a new lexicon

B Dubois, HH Feldman, C Jacova… - The Lancet …, 2010 - thelancet.com
Alzheimer's disease (AD) is classically defined as a dual clinicopathological entity. The
recent advances in use of reliable biomarkers of AD that provide in-vivo evidence of the …

Structural imaging of hippocampal subfields in healthy aging and Alzheimer's disease

R De Flores, R La Joie, G Chételat - Neuroscience, 2015 - Elsevier
Hippocampal atrophy, as evidenced using magnetic resonance imaging (MRI), is one of the
most validated, easily accessible and widely used biomarkers of Alzheimer's disease (AD) …

[HTML][HTML] Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer's pathology

TW Schmitz, R Nathan Spreng - Nature communications, 2016 - nature.com
There is considerable debate whether Alzheimer's disease (AD) originates in basal
forebrain or entorhinal cortex. Here we examined whether longitudinal decreases in basal …