Asthma is the result of a complex interaction between environmental factors and genetic
variants that confer susceptibility. Studies of the genetics of asthma have previously been …

Immunoglobulin E (IgE) mediated immune responses seem to be directed against parasites
and neoplasms, but are best known for their involvement in allergies. The IgE network is …

Background Farm exposure protects against development of allergies early in life. At 4.5
years, protection against asthma by farm‐milk exposure was partially mediated by regulatory …

Objective: Proton pump inhibitors (PPIs) are an effective treatment for eosinophilic
esophagitis (EoE); however, only 30% to 60% of patients respond. Common genetic variants …

BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease associated
with increased susceptibility to recurrent skin infections. OBJECTIVE: We sought to …

Background & Aims Based on histologic features, variants in STAT6 are associated with a
poor initial response to proton pump inhibitor (PPI) therapy in pediatric patients with …

Background Asthma is a common immune disorder characterized by increased IgE levels.
The interleukin (IL)-4 and IL-13 pathway is central for IgE regulation, and previous studies …

Previous studies have suggested an important role for the Janus kinase‐signal transducer
and activator of transcription (JAK‐STAT) signalling pathway in tumour development …

An imbalance between T Helper 1 (TH1) and T Helper 2 (TH2) cytokine production is
important for the pathogenesis of systemic lupus erythematosus (SLE). We aimed to …

Background Asthma is a complex disease influenced by multiple genetic and environmental
factors. While Madeira has the highest prevalence of asthma in Portugal (14.6%), the effect …