Purpose: The increasing burden of invasive fungal infections results in growing challenges
to antifungal (AF) therapeutic drug monitoring (TDM). This review aims to provide an …

Pharmacogenomics (PGx) enables personalized treatment for the prediction of drug
response and to avoid adverse drug reactions. Currently, PGx mainly relies on the genetic …

Organic cation transporters (OCT), organic anion transporting polypeptides (OATP) and
organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role …

Introduction Perinatal asphyxia (PA) still causes significant morbidity and mortality.
Therapeutic hypothermia (TH) is the only effective therapy for neonates with moderate to …

Piroxicam is a non-steroidal anti-inflammatory drug used to alleviate symptoms of
osteoarthritis and rheumatoid arthritis. CYP2C9 genetic polymorphism significantly …

The anticonvulsant carbamazepine is frequently used in the long-term therapy of epilepsy
and is a known substrate and inducer of cytochrome P450 (CYP) 3A4 and CYP2B6 …

Metoprolol, a selective β1-adrenoreceptor blocking agent used in the treatment of
hypertension, angina, and heart failure, is primarily metabolized by the CYP2D6 enzyme …

Adverse drug reactions (ADRs) account for a large proportion of hospitalizations among
adults and are more common in multimorbid patients, worsening clinical outcomes and …

ABSTRACT Introduction Adverse drug reactions (ADRs) are among the leading causes of
death, and frequently associated with drug–gene interactions (DGIs). In addition to …

Organic-anion-transporting polypeptide 1B1 (OATP1B1), encoded by the solute carrier
organic anion transporter family member 1B1 gene (SLCO1B1), is highly expressed in the …