Poorly water-soluble drugs continue to be a problematic, yet important class of
pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in …

Co-amorphous drug delivery systems (CAMS) are characterized by the combination of two
or more (initially crystalline) low molecular weight components that form a homogeneous …

In recent years, the coamorphous drug delivery system has been established as a promising
formulation approach for delivering poorly water-soluble drugs. The coamorphous solid is a …

Mechanochemistry is considered an alternative attractive greener approach to prepare
diverse molecular compounds and has become an important synthetic tool in different fields …

The availability of in vitro tools that are constructed on the basis of a detailed knowledge of
key aspects of gastrointestinal (GI) physiology and their impact on formulation performance …

Introduction Most new drug candidates under development are poorly water-soluble, which
are related to multiple pharmaceutical issues, increasing the bioavailability of these drugs by …

After decades of research, nanotechnology has been used in a broad array of biomedical
products including medical devices, drug products, drug substances, and pharmaceutical …

Co-amorphous drug delivery systems are evolving as a credible alternative to amorphous
solid dispersions technology. In Co-amorphous systems (CAMs), a drug is stabilized in …

Novel drug delivery systems exhibit great potential in the formulation of poorly soluble
compounds but have also been applied to reduce side effects of highly active drug …

In this study, we used molecular simulations to design Ceritinib (CRT) co-amorphous
materials (CAMs) with concurrent improvement in solubility and bioavailability …