Bone pain in cancer patients: mechanisms and current treatment

R Zajączkowska, M Kocot-Kępska, W Leppert… - International journal of …, 2019 - mdpi.com
The skeletal system is the third most common site for cancer metastases, surpassed only by
the lungs and liver. Many tumors, especially those of the breast, prostate, lungs, and …

Potential mechanisms and applications of statins on osteogenesis: Current modalities, conflicts and future directions

A Oryan, A Kamali, A Moshiri - Journal of controlled release, 2015 - Elsevier
Statins are known for their beneficial effects on cardiovascular diseases. Besides the lipid-
lowering properties, statins exert their anabolic effects on the bone by differentiating …

CX3CL1/fractalkine enhances prostate cancer spinal metastasis by activating the Src/FAK pathway

P Liu, Y Liang, L Jiang, H Wang… - … journal of oncology, 2018 - spandidos-publications.com
Chemokines serve important roles in the development of cancer. C-X3-C motif chemokine
ligand 1 (CX3CL1) has been demonstrated to promote metastases in different types of …

TMPRSS2-ERG fusion promotes prostate cancer metastases in bone

R Deplus, C Delliaux, N Marchand, A Flourens… - …, 2016 - pmc.ncbi.nlm.nih.gov
Bone metastasis is the major deleterious event in prostate cancer (PCa). TMPRSS2-ERG
fusion is one of the most common chromosomic rearrangements in PCa. However, its …

Cell Membrane‐Camouflaged Chitosan‐Polypyrrole Nanogels Co‐Deliver Drug and Gene for Targeted Chemotherapy and Bone Metastasis Inhibition of Prostate …

Q Yu, Y Gao, W Dai, D Li, L Zhang… - Advanced …, 2024 - Wiley Online Library
The development of functional nanoplatforms to improve the chemotherapy outcome and
inhibit distal cancer cell metastasis remains an extreme challenge in cancer management. In …

[HTML][HTML] Design and synthesis of chitosan/agar/Ag NPs: A potent and green bio-nanocomposite for the treatment of glucocorticoid induced osteoporosis in rats

D Shi, B Karmakar, HEH Osman, AF El-kott… - Arabian Journal of …, 2022 - Elsevier
In this work we have demonstrated the green synthesis of stable and mono-dispersed Ag
NPs using chitosan/Agar hydrogel having reducing/stabilizing ability avoiding any toxic …

Role of exosomes in prostate cancer bone metastasis

T Lv, Z Li, D Wang, X Guo, X Zhang, J Cao… - Archives of biochemistry …, 2023 - Elsevier
Bone is a preferred metastatic site of prostate cancer (PCa), and most patients with PCa
metastases develop osteogenic bone metastasis, which manifests as disturbed bone …

[68Ga]PSMA-HBED-CC Uptake in Osteolytic, Osteoblastic, and Bone Marrow Metastases of Prostate Cancer Patients

JC Janssen, N Woythal, S Meißner, V Prasad… - Molecular Imaging and …, 2017 - Springer
Purpose The aim of this study was to evaluate potential differences in “Glu-NH-CO-NH-Lys”
radio-labeled with [68 Ga] gallium N, N-bis [2-hydroxy-5-(carboxyethyl) benzyl] …

[HTML][HTML] Cellular senescence in metastatic prostate cancer: A therapeutic opportunity or challenge

C Jin, S Liao, G Lu, BD Geng, Z Ye… - Molecular …, 2024 - spandidos-publications.com
The treatment of patients with metastatic prostate cancer (PCa) is considered to be a long‑
standing challenge. Conventional treatments for metastatic PCa, such as radical …

Vertebral and femoral bone mineral density and bone strength in prostate cancer patients assessed in phantomless PET/CT examinations

BJ Schwaiger, DL Kopperdahl, L Nardo, L Facchetti… - Bone, 2017 - Elsevier
Purpose Bone fracture risk assessed ancillary to positron emission tomography with
computed tomography co-registration (PET/CT) could provide substantial clinical value to …