Macrophages are versatile and heterogeneous innate immune cells undertaking central
functions in balancing immune responses and tissue repair to maintain homeostasis. This …

Over the past few decades, substantial evidence has convincingly revealed the existence of
cancer stem cells (CSCs) as a minor subpopulation in cancers, contributing to an aberrantly …

Nitric oxide and its production by iNOS is an established mechanism critical to tumor
promotion or suppression. Macrophages have important roles in immunity, development …

Tumours display considerable variation in the patterning and properties of angiogenic blood
vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming …

The tumor microenvironment (TME) is a critical regulator of tumor growth, progression, and
metastasis. Among the innate immune cells recruited to the tumor site, macrophages are the …

Macrophages represent a heterogeneous cell population and are known to display a
remarkable plasticity. In response to distinct micro-environmental stimuli, eg, tumor stroma …

Inflammation is a hallmark of virtually all liver diseases, such as liver cancer, fibrosis,
nonalcoholic steatohepatitis, alcoholic liver disease, and cholangiopathies. Liver …

Established evidence demonstrates that tumor-infiltrating myeloid cells promote rather than
stop-cancer progression. Tumor-associated macrophages (TAMs) are abundantly present at …

Experimental and clinical evidence suggests that tumor-associated macrophages (TAMs)
play important roles in cancer progression. Here, we have characterized the ontogeny and …

Atherosclerosis is a chronic disease starting with the entry of monocytes into the
subendothelium and the subsequent differentiation into macrophages. Macrophages are the …