Betaine in inflammation: mechanistic aspects and applications

G Zhao, F He, C Wu, P Li, N Li, J Deng, G Zhu… - Frontiers in …, 2018 - frontiersin.org
Betaine is known as trimethylglycine and is widely distributed in animals, plants, and
microorganisms. Betaine is known to function physiologically as an important …

Selenium and selenoproteins: from endothelial cytoprotection to clinical outcomes

EL Junior, HP Leite, T Konstantyner - Translational Research, 2019 - Elsevier
The role of the vascular endothelium in inflammation was demonstrated experimentally
through biomarkers of endothelial dysfunction and cytoprotection. Selenium is a trace …

Astaxanthin Attenuates Homocysteine-Induced Cardiotoxicity in Vitro and in Vivo by Inhibiting Mitochondrial Dysfunction and Oxidative Damage

C Fan, J Sun, X Fu, Y Hou, Y Li, M Yang, X Fu… - Frontiers in …, 2017 - frontiersin.org
Homocysteine (Hcy) as an independent risk factor contributes to the occurrence and
development of human cardiovascular diseases (CVD). Induction of oxidative stress and …

Anti-nociceptive and antioxidant activity of betaine on formalin-and writhing tests induced pain in mice

S Hassanpour, H Rezaei, SM Razavi - Behavioural brain research, 2020 - Elsevier
Pain is a physiological response which is mediated via the central and peripheral nervous
system. Betaine, is a methyl glycine derivative and a commonly used nutrient supplement …

Betaine suppresses cell proliferation by increasing oxidative stress–mediated apoptosis and inflammation in DU-145 human prostate cancer cell line

F Kar, C Hacioglu, S Kacar, V Sahinturk… - Cell Stress and …, 2019 - Springer
Prostate cancer is the main cause of cancer-related mortality in men around the world and
an important health problem. DU-145 human prostate cancer cells provide an opportunity to …

[HTML][HTML] Selenium inhibits homocysteine-induced endothelial dysfunction and apoptosis via activation of AKT

H Ren, J Mu, J Ma, J Gong, J Li, J Wang… - Cellular Physiology and …, 2016 - karger.com
Background/Aims: Endothelial cells are crucial in vascular homeostasis. Dysfunction of
endothelial cells is involved in the development of cardiovascular diseases (CVD). High …

Gallic acid protects against isoproterenol-induced cardiotoxicity in rats

D Shackebaei, M Hesari… - Human & …, 2022 - journals.sagepub.com
Background Gallic acid (GA) is a polyphenolic agent with interesting pharmacological
impacts on the cardiovascular system. Objective The present study purposed to study the …

[HTML][HTML] Oxymatrine inhibits homocysteine-mediated autophagy via MIF/mTOR signaling in human umbilical vein endothelial cells

Y Zhang, Y Zhang, J Tang, S Zhao, C Li… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Genetic or nutritional deficiencies in homocysteine (Hcy) metabolism lead
to the accumulation of Hcy and its metabolites in the blood. This can lead to …

[HTML][HTML] Betaine Intervention as a Novel Approach to Preventing Doxorubicin-Induced Cardiotoxicity

A Jaiswal, PS Rawat, SK Singh, JS Bhatti… - Advances in redox …, 2023 - Elsevier
The anthracycline anticancer drug doxorubicin (Dox) is widely prescribed for treating lung,
ovary, breast, lymphoma, sarcoma, and pediatric cancer. Mechanistically, Dox intercalates …

MTHFR C677T gene polymorphism and the severity of coronary lesions in acute coronary syndrome

MN Li, HJ Wang, NR Zhang, L Xuan, XJ Shi, T Zhou… - Medicine, 2017 - journals.lww.com
MTHFR C677T gene polymorphism and the severity of coronary l... : Medicine MTHFR C677T
gene polymorphism and the severity of coronary lesions in acute coronary syndrome : Medicine …