The administration of drugs to the central nervous system (CNS) is primarily controlled by
the blood-brain barrier (BBB), a structure that prevents the passage of foreign compounds …

Localized or topical administration of drugs may be considered as a potential approach for
overcoming the problems caused by the various biological barriers encountered in drug …

Liposomes are safe, biocompatible, and biodegradable spherical nanosized vesicles
produced from cholesterol and phospholipids. Recently, liposomes have been widely …

Huntington's disease (HD) is an autosomal dominant genetic disorder caused by an
expansion of the CAG repeat in the first exon of Huntingtin's gene. The associated …

Neurodegenerative diseases (NDs) represent a heterogeneous group of aging-related
disorders featured by progressive impairment of motor and/or cognitive functions, often …

Cholesterol is an important metabolite and membrane component and is enriched in the
brain owing to its role in neuronal maturation and function. In the adult brain, cholesterol is …

Brain is by far the most complex organ in the body. It is involved in the regulation of
cognitive, behavioral, and emotional activities. The organ is also a target for many diseases …

Supplementing brain cholesterol is emerging as a potential treatment for Huntington's
disease (HD), a genetic neurodegenerative disorder characterized, among other …

Huntington's disease (HD) is an autosomal fatal genetic disease in which degeneration of
neuronal cells occurs in the central nervous system (CNS). Commonly used therapeutics are …

Parkinson's disease (PD) is a severe neurodegenerative disease with a high incidence in
the elderly and is mainly treated by drugs. The blood–brain barrier (BBB) limits the entry of …