Bioanalysis of ibrutinib and its active metabolite in human plasma: selectivity issue, impact assessment and resolution
R de Vries, M Huang, N Bode, P Jejurkar, J Jong… - Bioanalysis, 2015 - Taylor & Francis
Ronald de Vries graduated in Organic and Analytical Chemistry at the Free University of
Amsterdam, The Netherlands. After working in a Contract Laboratory (CRO) for 7 years, he …
Amsterdam, The Netherlands. After working in a Contract Laboratory (CRO) for 7 years, he …
Recent developments in the chromatographic bioanalysis of approved kinase inhibitor drugs in oncology
JJM Rood, JHM Schellens, JH Beijnen… - … of Pharmaceutical and …, 2016 - Elsevier
Abstract In recent years (2010-present) there has been an increase in the number of
publications reporting the development, validation and use of bioanalytical methods in the …
publications reporting the development, validation and use of bioanalytical methods in the …
Development and validation of liquid chromatography method for determination of Ibrutinib in finished dosage forms using quality by design approach
A simple, precise, linear, robust, accurate, and stability‐indicating liquid chromatography
method was developed and validated to determine Ibrutinib in finished solid dosage forms …
method was developed and validated to determine Ibrutinib in finished solid dosage forms …
An LC–MS/MS method for rapid and sensitive high‐throughput simultaneous determination of various protein kinase inhibitors in human plasma
AS Abdelhameed, MW Attwa… - Biomedical …, 2017 - Wiley Online Library
A reliable, high‐throughput and sensitive LC–MS/MS procedure was developed and
validated for the determination of five tyrosine kinase inhibitors in human plasma. Following …
validated for the determination of five tyrosine kinase inhibitors in human plasma. Following …
Development and validation of a stability-indicating method for ibrutinib: Identification and separation of degradation products, known and genotoxic impurities using …
The present work describes a novel stability-indicating method development and validation
for separation and identification of degradation products, known and genotoxic impurities in …
for separation and identification of degradation products, known and genotoxic impurities in …
Development and validation of an UHPLC-MS/MS method for simultaneous quantification of ibrutinib and its dihydrodiol-metabolite in human cerebrospinal fluid
D Beauvais, JF Goossens, E Boyle, B Allal… - … of Chromatography B, 2018 - Elsevier
Ibrutinib is an orally administered first-in-class irreversible Bruton's tyrosine kinase (BTK)
covalent inhibitor for the treatment of patients with B-cell malignancies. Several isolated …
covalent inhibitor for the treatment of patients with B-cell malignancies. Several isolated …
[HTML][HTML] Bioanalysis of ibrutinib, and its dihydrodiol-and glutathione cycle metabolites by liquid chromatography-tandem mass spectrometry
JJM Rood, PJA Dormans, MJ Van Haren… - … of Chromatography B, 2018 - Elsevier
Ibrutinib is a targeted covalent inhibitor frequently used for the treatment of various
lymphomas. In addition to oxidative metabolism, it is metabolized through glutathione …
lymphomas. In addition to oxidative metabolism, it is metabolized through glutathione …
Efficacy of afatinib, an irreversible ErbB family blocker, in the treatment of intracerebral metastases of non-small cell lung cancer in mice
S Zhang, L Zhu, Y Jiang, J Zhang, R Xu, Y Xu… - Acta Pharmacologica …, 2017 - nature.com
Few effective therapeutic options are currently available for the treatment of non-small cell
lung cancer (NSCLC) with brain metastases (BM). Recent evidence shows that NSCLC …
lung cancer (NSCLC) with brain metastases (BM). Recent evidence shows that NSCLC …
Liquid chromatographic-tandem mass spectrometric assay for simultaneous quantitation of tofacitinib, cabozantinib and afatinib in human plasma and urine
Purpose: To develop a simple, adequately sensitive, and practical liquid chromatographic-
mass spectrometric method to simultaneously quantify three tyrosine kinase inhibitors, viz …
mass spectrometric method to simultaneously quantify three tyrosine kinase inhibitors, viz …
A highly efficient and sensitive LC‐MS/MS method for the determination of afatinib in human plasma: application to a metabolic stability study
Afatinib (AFT) is a new tyrosine kinase inhibitor approved for the treatment of nonsmall cell
lung cancer. In the present study, a simple, specific, rapid and sensitive liquid …
lung cancer. In the present study, a simple, specific, rapid and sensitive liquid …