[HTML][HTML] Apoptotic cell death in disease—Current understanding of the NCCD 2023

I Vitale, F Pietrocola, E Guilbaud… - Cell Death & …, 2023 - nature.com
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

TNF and TNF receptors as therapeutic targets for rheumatic diseases and beyond

D Siegmund, H Wajant - Nature Reviews Rheumatology, 2023 - nature.com
The cytokine TNF signals via two distinct receptors, TNF receptor 1 (TNFR1) and TNFR2,
and is a central mediator of various immune-mediated diseases. Indeed, TNF-neutralizing …

Selective inhibition of soluble TNF using XPro1595 improves hippocampal pathology to promote improved neurological recovery following traumatic brain injury in …

K Larson, M Damon, R Randhi… - CNS & Neurological …, 2023 - ingentaconnect.com
Aims: To determine the efficacy of XPro1595 to improve pathophysiological and functional
outcomes in a mouse model of traumatic brain injury (TBI). Background: Symptoms …

The Role of Tnf and Soluble Tnf Receptors (TNFR1/2) as Therapeutic Targets for Inflammation Secondary to Intracerebral Stroke and Hemorrhage

R Alshaibi, K Ekanayake, E Barlow, AA Mohamed… - 2024 - preprints.org
Most neurodegenerative diseases, including Alzheimer's disease, ischemic stroke,
subarachnoid hemorrhage, and intracerebral hemorrhage are associated with inflammation …

[图书][B] Effects of TNFR1 Inhibition on Neuropathological Outcomes in a Controlled Cortical Impact Mouse Model of Traumatic Brain Injury

E Hayashi - 2023 - search.proquest.com
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality around the world. It
has multiple causative factors including sports injuries, vehicular accidents, war, and other …