Mitochondria are essential for the viability of eukaryotic cells as they perform crucial
functions in bioenergetics, metabolism and signalling and have been associated with …

Mitochondria are essential organelles with numerous functions in cellular metabolism and
homeostasis. Most of the> 1,000 different mitochondrial proteins are synthesized as …

The presequence translocase of the mitochondrial inner membrane (TIM23) represents the
major route for the import of nuclear-encoded proteins into mitochondria,. About 60% of …

Efficient movement of proteins across membranes is required for cell health. The
translocation process is particularly challenging when the channel in the membrane through …

Mitochondria perform crucial functions in cellular metabolism, protein and lipid biogenesis,
quality control, and signaling. The systematic analysis of protein complexes and interaction …

The biogenesis of mitochondria depends on the import of hundreds of preproteins. N-
terminal matrix-targeting signals (MTSs) direct preproteins to the surface receptors Tom20 …

The majority of organellar proteins are translated on cytosolic ribosomes and must be sorted
correctly to function. Targeting routes have been identified for organelles such as …

Mitochondria import nearly all of their approximately 1,000–2,000 constituent proteins from
the cytosol across their double-membrane envelope,,,–. Genetic and biochemical studies …

Mitochondria contain two aqueous subcompartments, the matrix and the intermembrane
space (IMS). The matrix is enclosed by both the inner and outer mitochondrial membranes …

Mitochondria are essential organelles of eukaryotic cells. They consist of hundreds of
different proteins that exhibit crucial activities in respiration, catabolic metabolism and the …