Cell-free DNA-based liquid biopsies in neurology

H Gaitsch, RJM Franklin, DS Reich - Brain, 2023 - academic.oup.com
This article reviews recent developments in the application of cell-free DNA-based liquid
biopsies to neurological diseases. Over the past few decades, an explosion of interest in the …

Liquid biopsy in neurological diseases

S Malhotra, MCM Miras, A Pappolla, X Montalban… - Cells, 2023 - mdpi.com
The most recent and non-invasive approach for studying early-stage biomarkers is liquid
biopsy. This implies the extraction and analysis of non-solid biological tissues (serum …

Pathogenetic mechanisms and treatment targets in cerebral malaria

A Hadjilaou, J Brandi, M Riehn, MA Friese… - Nature Reviews …, 2023 - nature.com
Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …

[HTML][HTML] Determinants of brain swelling in pediatric and adult cerebral malaria

PK Sahu, FJ Duffy, S Dankwa, M Vishnyakova… - JCI insight, 2021 - ncbi.nlm.nih.gov
Cerebral malaria (CM) affects children and adults, but brain swelling is more severe in
children. To investigate features associated with brain swelling in malaria, we performed …

The spectrum of clinical biomarkers in severe malaria and new avenues for exploration

LPK Foko, G Narang, S Tamang, J Hawadak, J Jakhan… - Virulence, 2022 - Taylor & Francis
Globally, malaria is a public health concern, with severe malaria (SM) contributing a major
share of the disease burden in malaria endemic countries. In this context, identification and …

Pro-thrombotic autoantibodies targeting Platelet Factor 4/polyanion are associated with pediatric cerebral malaria

IM Vera, A Kessler, V Harawa… - The Journal of …, 2024 - Am Soc Clin Investig
BACKGROUND. Features of consumptive coagulopathy and thromboinflammation are
prominent in cerebral malaria (CM). We hypothesized that thrombogenic autoantibodies …

Elevated plasma interleukin-8 as a risk factor for mortality in children presenting with cerebral malaria

J Royo, B Vianou, M Accrombessi, E Kinkpé… - Infectious Diseases of …, 2023 - mednexus.org
Background Cerebral malaria (CM) is a neuropathology which remains one of the deadliest
forms of malaria among African children. The kinetics of the pathophysiological mechanisms …

The rising tide of cell-free DNA profiling: from snapshot to temporal genome analysis

AJ Bronkhorst, V Ungerer, A Oberhofer… - Journal of Laboratory …, 2022 - degruyter.com
Genomes of diverse origins are continuously shed into human body fluids in the form of
fragmented cell-free DNA (cfDNA). These molecules maintain the genetic and epigenetic …

Cell-free DNA: a promising biomarker in infectious diseases

Y Hu, Y Zhao, Y Zhang, W Chen, H Zhang, X Jin - Trends in Microbiology, 2024 - cell.com
Infectious diseases pose serious threats to public health worldwide. Conventional diagnostic
methods for infectious diseases often exhibit low sensitivity, invasiveness, and long …

Bioengineered 3D microvessels for investigating Plasmodium falciparum pathogenesis

M Bernabeu, C Howard, Y Zheng, JD Smith - Trends in parasitology, 2021 - cell.com
Plasmodium falciparum pathogenesis is complex and intimately connected to vascular
physiology. This is exemplified by cerebral malaria (CM), a neurovascular complication that …