Cell-free DNA-based liquid biopsies in neurology
This article reviews recent developments in the application of cell-free DNA-based liquid
biopsies to neurological diseases. Over the past few decades, an explosion of interest in the …
biopsies to neurological diseases. Over the past few decades, an explosion of interest in the …
Liquid biopsy in neurological diseases
S Malhotra, MCM Miras, A Pappolla, X Montalban… - Cells, 2023 - mdpi.com
The most recent and non-invasive approach for studying early-stage biomarkers is liquid
biopsy. This implies the extraction and analysis of non-solid biological tissues (serum …
biopsy. This implies the extraction and analysis of non-solid biological tissues (serum …
Pathogenetic mechanisms and treatment targets in cerebral malaria
Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …
humanity for millennia and remains an important public health issue despite advances in its …
[HTML][HTML] Determinants of brain swelling in pediatric and adult cerebral malaria
Cerebral malaria (CM) affects children and adults, but brain swelling is more severe in
children. To investigate features associated with brain swelling in malaria, we performed …
children. To investigate features associated with brain swelling in malaria, we performed …
The spectrum of clinical biomarkers in severe malaria and new avenues for exploration
LPK Foko, G Narang, S Tamang, J Hawadak, J Jakhan… - Virulence, 2022 - Taylor & Francis
Globally, malaria is a public health concern, with severe malaria (SM) contributing a major
share of the disease burden in malaria endemic countries. In this context, identification and …
share of the disease burden in malaria endemic countries. In this context, identification and …
Pro-thrombotic autoantibodies targeting Platelet Factor 4/polyanion are associated with pediatric cerebral malaria
IM Vera, A Kessler, V Harawa… - The Journal of …, 2024 - Am Soc Clin Investig
BACKGROUND. Features of consumptive coagulopathy and thromboinflammation are
prominent in cerebral malaria (CM). We hypothesized that thrombogenic autoantibodies …
prominent in cerebral malaria (CM). We hypothesized that thrombogenic autoantibodies …
Elevated plasma interleukin-8 as a risk factor for mortality in children presenting with cerebral malaria
J Royo, B Vianou, M Accrombessi, E Kinkpé… - Infectious Diseases of …, 2023 - mednexus.org
Background Cerebral malaria (CM) is a neuropathology which remains one of the deadliest
forms of malaria among African children. The kinetics of the pathophysiological mechanisms …
forms of malaria among African children. The kinetics of the pathophysiological mechanisms …
The rising tide of cell-free DNA profiling: from snapshot to temporal genome analysis
AJ Bronkhorst, V Ungerer, A Oberhofer… - Journal of Laboratory …, 2022 - degruyter.com
Genomes of diverse origins are continuously shed into human body fluids in the form of
fragmented cell-free DNA (cfDNA). These molecules maintain the genetic and epigenetic …
fragmented cell-free DNA (cfDNA). These molecules maintain the genetic and epigenetic …
Cell-free DNA: a promising biomarker in infectious diseases
Y Hu, Y Zhao, Y Zhang, W Chen, H Zhang, X Jin - Trends in Microbiology, 2024 - cell.com
Infectious diseases pose serious threats to public health worldwide. Conventional diagnostic
methods for infectious diseases often exhibit low sensitivity, invasiveness, and long …
methods for infectious diseases often exhibit low sensitivity, invasiveness, and long …
Bioengineered 3D microvessels for investigating Plasmodium falciparum pathogenesis
Plasmodium falciparum pathogenesis is complex and intimately connected to vascular
physiology. This is exemplified by cerebral malaria (CM), a neurovascular complication that …
physiology. This is exemplified by cerebral malaria (CM), a neurovascular complication that …