From bacteria to mammalian cells, damaged DNA is sensed and targeted by DNA repair
pathways. In eukaryotes, kinases play a central role in coordinating the DNA damage …

In order to preserve genome integrity and their ploidy, cells must ensure that the duplicated
genome has been faithfully replicated and evenly distributed before they complete their …

GTPase signal transduction pathways control cellular decision making by integrating
multiple cellular events into a single signal. The Mitotic Exit Network (MEN), a Ras-like …

Polo-like kinases are essential cell cycle regulators that are conserved from yeast to
humans. Unlike higher eukaryotes, who express multiple Polo-like kinase family members …

Abstract The Mitotic Exit Network (MEN) is an essential signaling pathway, closely related to
the Hippo pathway in mammals, which promotes mitotic exit and initiates cytokinesis in the …

Morphogenesis in filamentous fungi depends on appropriate cell cycle progression. Here,
we report that cells of the cucumber anthracnose fungus Colletotrichum orbiculare regulate …

During evolution, cells have developed a plethora of mechanisms to optimize survival in a
changing and unpredictable environment. In this regard, they have evolved networks that …

The asymmetrically dividing yeast S. cerevisiae assembles a bipolar spindle well after
establishing the future site of cell division (ie, the bud neck) and the division axis (ie, the …

Both the spindle microtubule-organizing centers and the nuclear pore complexes (NPCs)
are convoluted structures where many signaling pathways converge to coordinate key …

DNA double strand breaks (DSBs) pose a high risk for genome integrity. Cells repair DSBs
through homologous recombination (HR) when a sister chromatid is available. HR is …