The therapeutic potential of purified cannabidiol

SE O'Sullivan, SS Jensen, GN Nikolajsen… - Journal of Cannabis …, 2023 - Springer
The use of cannabidiol (CBD) for therapeutic purposes is receiving considerable attention,
with speculation that CBD can be useful in a wide range of conditions. Only one product, a …

Adverse effects of oral cannabidiol: an updated systematic review of randomized controlled trials (2020–2022)

JDR Souza, JC Pacheco, GN Rossi, BO de-Paulo… - Pharmaceutics, 2022 - mdpi.com
(1) Background: With the massive demand for the use and commercialization of medicinal
cannabidiol (CBD) products, new randomized clinical trials (RCTs) are being published …

Anxiolytic-like effect of succinic acid: a possible GABAergic intervention

MN Mia, SZ Smrity, MH Bappi, H Kamli, T Islam… - Food Bioscience, 2023 - Elsevier
In the modern era, physical and mental stress lead to anxiety at an alarming rate. Therefore,
searching for new lead compounds that deal with anxiety has a practical demand. Our study …

Co-dispersion delivery systems with solubilizing carriers improving the solubility and permeability of cannabinoids (cannabidiol, cannabidiolic acid, and …

A Stasiłowicz-Krzemień, P Szulc, J Cielecka-Piontek - Pharmaceutics, 2023 - mdpi.com
Cannabinoids: cannabidiol (CBD), cannabidiolic acid (CBDA), and cannabichromene (CBC)
are lipophilic compounds with limited water solubility, resulting in challenges related to their …

Cannabinoids for substance use disorder treatment: What does the current evidence say?

JAB Fernandes, R Filev, TM Fidalgo - Cannabis and Cannabinoid …, 2023 - liebertpub.com
Background: The prevalence of Substance Use Disorder (SUD) is increasing along with the
need to develop approaches to reduce the harm associated with substance use, including …

Dr. Raphael Mechoulam, cannabis and cannabinoids research pioneer (November 5, 1930–March 9, 2023) and his legacy for Brazilian pharmacology

JAS Crippa, FS Guimarães, AW Zuardi… - Brazilian Journal of …, 2023 - SciELO Brasil
Israeli researcher Raphael Mechoulam, the father of cannabis research, passed away on
March 10, 2023, at 92 years of age. In early 1960, he was the first to reveal the structure of …

Potential strategies for supporting mental health and mitigating the risk of burnout among healthcare professionals: insights from the COVID-19 pandemic

G Collett, A Korszun, AK Gupta - EClinicalMedicine, 2024 - thelancet.com
Healthcare professionals (HCPs) experienced prolonged stressful conditions during the
coronavirus disease 2019 pandemic, and the global situation (particularly in the United …

Chronic Cannabidiol Administration Mitigates Excessive Daytime Sleepiness and Fatigue in Patients with Primary Hypertension: Insights from a Randomized …

G Dujic, M Kumric, J Vrdoljak, D Sutlovic… - Cannabis and …, 2024 - liebertpub.com
Background: The chronic effects of cannabidiol (CBD) supplementation on factors that could
impact the quality of life (anxiety, sleeping quality, memory, etc.) are poorly explored. Hence …

Anxiolytic-like effect of daidzin possibly through GABAA receptor α2 and α3 subunits interaction pathway: in vivo and in silico studies

MT Islam, AAS Prottay, MS Akbor, MS Bhuia… - Pharmacological …, 2024 - Elsevier
The soy plant-derived isoflavone daidzin (DZN) has diverse biological activities, including
neuroprotective (eg, memory-enhancing and antiepileptic) effects. This study emphasizes …

Cannabidiol in anxiety disorders: Current and future perspectives.

JLQ Simei, JDR de Souza, JR Lisboa… - International Review …, 2024 - europepmc.org
Anxiety disorders are highly prevalent psychiatric disorders, characterized by a chronic
course and often accompanied by comorbid symptoms that impair functionality and …