New insights into the degradation of synthetic pollutants in contaminated environments

P Bhatt, S Gangola, G Bhandari, W Zhang, D Maithani… - Chemosphere, 2021 - Elsevier
The environment is contaminated by synthetic contaminants owing to their extensive
applications globally. Hence, the removal of synthetic pollutants (SPs) from the environment …

Recent advances in assessment methods and mechanism of microbe-mediated chlorpyrifos remediation

A Raj, A Kumar - Environmental Research, 2022 - Elsevier
Chlorpyrifos (CP) is one of the Organophosphorus pesticides (OPs) primarily used in
agriculture to safeguard crops from pests and diseases. The pervasive use of chlorpyrifos is …

Gene editing and systems biology tools for pesticide bioremediation: a review

S Jaiswal, DK Singh, P Shukla - Frontiers in microbiology, 2019 - frontiersin.org
Bioremediation is the degradation potential of microorganisms to dissimilate the complex
chemical compounds from the surrounding environment. The genetics and biochemistry of …

Deciphering the recent trends in pesticide bioremediation using genome editing and multi-omics approaches: A review

S Hassan, BA Ganai - World Journal of Microbiology and Biotechnology, 2023 - Springer
Pesticide pollution in recent times has emerged as a grave environmental problem
contaminating both aquatic and terrestrial ecosystems owing to their widespread use …

Genomic and epigenetic landscapes drive CRISPR-based genome editing in Bifidobacterium

M Pan, W Morovic… - Proceedings of the …, 2022 - National Acad Sciences
Bifidobacterium is a commensal bacterial genus ubiquitous in the human gastrointestinal
tract, which is associated with a range of health benefits. The advent of CRISPR-based …

Endogenous CRISPR-Cas mediated in situ genome editing: State-of-the-art and the road ahead for engineering prokaryotes

Z Liu, J Liu, Z Yang, L Zhu, Z Zhu, H Huang… - Biotechnology …, 2023 - Elsevier
The CRISPR-Cas systems have shown tremendous promise as heterologous tools for
genome editing in various prokaryotes. However, the perturbation of DNA homeostasis and …

DNA targeting by subtype ID CRISPR–Cas shows type I and type III features

J Lin, A Fuglsang, AL Kjeldsen, K Sun… - Nucleic Acids …, 2020 - academic.oup.com
Prokaryotic CRISPR–Cas immune systems are classified into six types based on their
effector complexes which cleave dsDNA specifically (types I, II and V), ssRNA exclusively …

Regulation of the RNA and DNA nuclease activities required for Pyrococcus furiosus Type III-B CRISPR–Cas immunity

K Foster, S Grüschow, S Bailey, MF White… - Nucleic acids …, 2020 - academic.oup.com
Abstract Type III CRISPR–Cas prokaryotic immune systems provide anti-viral and anti-
plasmid immunity via a dual mechanism of RNA and DNA destruction. Upon target RNA …

The toxin–antitoxin RNA guards of CRISPR-Cas evolved high specificity through repeat degeneration

F Cheng, A Wu, C Liu, X Cao, R Wang… - Nucleic Acids …, 2022 - academic.oup.com
Recent discovery of ectopic repeats (outside CRISPR arrays) provided unprecedented
insights into the nondefense roles of CRISPR-Cas. A striking example is the addiction …

Heavily armed ancestors: CRISPR immunity and applications in archaea with a comparative analysis of CRISPR types in sulfolobales

IA Zink, E Wimmer, C Schleper - Biomolecules, 2020 - mdpi.com
Prokaryotes are constantly coping with attacks by viruses in their natural environments and
therefore have evolved an impressive array of defense systems. Clustered Regularly …