Molecular imaging has experienced enormous advancements in the areas of imaging
technology, imaging probe and contrast development, and data quality, as well as machine …

The responses of patients to tumor therapies vary due to tumor heterogeneity. Tumor
stratification has been attracting increasing attention for accurately distinguishing between …

Tracking the immune microenvironment of tumours is essential for understanding the
mechanisms behind the effectiveness of cancer immunotherapies. Molecular imaging of …

Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

The development of targeted medicine has greatly expanded treatment options and spurred
new research avenues in cancer therapeutics, with monoclonal antibodies (mAbs) emerging …

Improving the efficacy of immune checkpoint therapies will require a better understanding of
how immune cells are recruited and sustained in tumors. Here, we used the …

Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells
in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal …

Real-time imaging of immunoactivation is imperative for cancer immunotherapy and drug
discovery; however, most existing imaging agents possess “always-on” signals and thus …

The therapeutic potential of recombinant cytokines has been limited by the severe side
effects of systemic administration. We describe a strategy to reduce the dose-limiting …

Trained immunity, a functional state of myeloid cells, has been proposed as a compelling
immune-oncological target. Its efficient induction requires direct engagement of myeloid …