Research showing that microRNAs (miRNAs) are versatile regulators of gene expression
has instigated tremendous interest in cardiovascular research. The overwhelming majority of …

Much of the mammalian genome is transcribed, generating long non-coding RNAs
(lncRNAs) that can undergo post-transcriptional surveillance whereby only a subset of the …

Noncoding RNAs are exquisitely titrated by the cellular RNA surveillance machinery for
regulating diverse biological processes. The RNA exosome, the predominant 3′ RNA …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Abstract Crick's Central Dogma has been a foundational aspect of 20th century biology,
describing an implicit relationship governing the flow of information in biological systems in …

Chromatin is a dynamic structure composed of DNA, RNA, and proteins, regulating storage
and expression of the genetic material in the nucleus. Heterochromatin plays a crucial role …

The nucleolus is the largest substructure in the nucleus, where ribosome biogenesis takes
place, and forms around the nucleolar organizer regions (NORs) that comprise ribosomal …

In interphase eukaryotic cells, almost all heterochromatin is located adjacent to the
nucleolus or to the nuclear lamina, thus defining nucleolus-associated domains (NADs) and …

Background: Small cell lung cancer (SCLC) is an extremely aggressive cancer type with a
patient median survival of 6-12 months. Epidermal growth factor (EGF) signaling plays an …

B cell development is linked to successful V (D) J recombination, allowing B cell receptor
expression and ultimately antibody secretion for adaptive immunity. Germline noncoding …