Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease
D Santovito, C Weber - Nature Reviews Cardiology, 2022 - nature.com
Research showing that microRNAs (miRNAs) are versatile regulators of gene expression
has instigated tremendous interest in cardiovascular research. The overwhelming majority of …
has instigated tremendous interest in cardiovascular research. The overwhelming majority of …
Regulation of long non-coding RNAs and genome dynamics by the RNA surveillance machinery
L Nair, H Chung, U Basu - Nature reviews Molecular cell biology, 2020 - nature.com
Much of the mammalian genome is transcribed, generating long non-coding RNAs
(lncRNAs) that can undergo post-transcriptional surveillance whereby only a subset of the …
(lncRNAs) that can undergo post-transcriptional surveillance whereby only a subset of the …
Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells
Noncoding RNAs are exquisitely titrated by the cellular RNA surveillance machinery for
regulating diverse biological processes. The RNA exosome, the predominant 3′ RNA …
regulating diverse biological processes. The RNA exosome, the predominant 3′ RNA …
A revised central dogma for the 21st century: All biology is cognitive information processing
Abstract Crick's Central Dogma has been a foundational aspect of 20th century biology,
describing an implicit relationship governing the flow of information in biological systems in …
describing an implicit relationship governing the flow of information in biological systems in …
Close to the edge: Heterochromatin at the nucleolar and nuclear peripheries
A Bizhanova, PD Kaufman - Biochimica et Biophysica Acta (BBA)-Gene …, 2021 - Elsevier
Chromatin is a dynamic structure composed of DNA, RNA, and proteins, regulating storage
and expression of the genetic material in the nucleus. Heterochromatin plays a crucial role …
and expression of the genetic material in the nucleus. Heterochromatin plays a crucial role …
Genome organization in and around the nucleolus
C Bersaglieri, R Santoro - Cells, 2019 - mdpi.com
The nucleolus is the largest substructure in the nucleus, where ribosome biogenesis takes
place, and forms around the nucleolar organizer regions (NORs) that comprise ribosomal …
place, and forms around the nucleolar organizer regions (NORs) that comprise ribosomal …
Two contrasting classes of nucleolus-associated domains in mouse fibroblast heterochromatin
In interphase eukaryotic cells, almost all heterochromatin is located adjacent to the
nucleolus or to the nuclear lamina, thus defining nucleolus-associated domains (NADs) and …
nucleolus or to the nuclear lamina, thus defining nucleolus-associated domains (NADs) and …
[HTML][HTML] Non-canonical integrin signaling activates EGFR and RAS-MAPK-ERK signaling in small cell lung cancer
Background: Small cell lung cancer (SCLC) is an extremely aggressive cancer type with a
patient median survival of 6-12 months. Epidermal growth factor (EGF) signaling plays an …
patient median survival of 6-12 months. Epidermal growth factor (EGF) signaling plays an …
RNA exosome drives early B cell development via noncoding RNA processing mechanisms
B cell development is linked to successful V (D) J recombination, allowing B cell receptor
expression and ultimately antibody secretion for adaptive immunity. Germline noncoding …
expression and ultimately antibody secretion for adaptive immunity. Germline noncoding …