[HTML][HTML] Neuroinflammation after intracerebral hemorrhage and potential therapeutic targets

C Tschoe, CD Bushnell, PW Duncan… - Journal of …, 2020 - ncbi.nlm.nih.gov
Spontaneous intracerebral hemorrhage (ICH) is a catastrophic illness causing significant
morbidity and mortality. Despite advances in surgical technique addressing primary brain …

Microglia and macrophage phenotypes in intracerebral haemorrhage injury: therapeutic opportunities

Q Bai, M Xue, VW Yong - Brain, 2020 - academic.oup.com
The prognosis of intracerebral haemorrhage continues to be devastating despite much
research into this condition. A prominent feature of intracerebral haemorrhage is …

Regulatory T cells in ischemic stroke

H Wang, J Ye, L Cui, S Chu, N Chen - Acta Pharmacologica Sinica, 2022 - nature.com
Recent evidence shows that when ischemic stroke (IS) occurs, the BBB would be destructed,
thereby promoting the immune cells to migrate into the brain, suggesting that the immune …

Immune response in neurological pathology: emerging role of central and peripheral immune crosstalk

AP Passaro, AL Lebos, Y Yao, SL Stice - Frontiers in immunology, 2021 - frontiersin.org
Neuroinflammation is a key component of neurological disorders and is an important
therapeutic target; however, immunotherapies have been largely unsuccessful. In cases …

Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions

RF Sîrbulescu, CK Boehm, E Soon… - Wound Repair and …, 2017 - Wiley Online Library
Abstract Chronic wounds affect 12–15% of patients with diabetes and are associated with a
drastic decrease in their quality of life. Here, we demonstrate that purified mature naive …

The immune response of T cells and therapeutic targets related to regulating the levels of T helper cells after ischaemic stroke

TY Lei, YZ Ye, XQ Zhu, D Smerin, LJ Gu… - Journal of …, 2021 - Springer
Through considerable effort in research and clinical studies, the immune system has been
identified as a participant in the onset and progression of brain injury after ischaemic stroke …

Dynamics of T cell responses after stroke

D Gill, R Veltkamp - Current opinion in pharmacology, 2016 - Elsevier
Highlights•T cells serve both inflammatory and protective roles in acute stroke.•Effects are
direct and through modulation of the inflammatory milieu.•Following the early phase, there is …

The peripheral immune response after stroke—A double edge sword for blood‐brain barrier integrity

Y Li, ZY Zhu, TT Huang, YX Zhou… - CNS neuroscience & …, 2018 - Wiley Online Library
The blood‐brain barrier (BBB) is a highly regulated interface that separates the peripheral
circulation and the brain. It plays a vital role in regulating the trafficking of solutes, fluid, and …

Germinal matrix-intraventricular hemorrhage of the preterm newborn and preclinical models: inflammatory considerations

I Atienza-Navarro, P Alves-Martinez… - International journal of …, 2020 - mdpi.com
The germinal matrix-intraventricular hemorrhage (GM-IVH) is one of the most important
complications of the preterm newborn. Since these children are born at a critical time in …

Chemerin suppresses neuroinflammation and improves neurological recovery via CaMKK2/AMPK/Nrf2 pathway after germinal matrix hemorrhage in neonatal rats

Y Zhang, N Xu, Y Ding, Y Zhang, Q Li, J Flores… - Brain, behavior, and …, 2018 - Elsevier
Chemerin, an adipokine, has been reported to reduce the production of pro-inflammatory
cytokines and neutrophil infiltration. This study investigated the role of Chemerin and its …