Skeletal muscle is one of the main regulators of carbohydrate and lipid metabolism in our
organism, and therefore, it is highly susceptible to changes in glucose and fatty acid (FA) …

Background Excess storage of lipids in ectopic tissues, such as skeletal muscle, liver, and
heart, seems to associate closely with metabolic abnormalities and cardiac disease …

Cytoplasmic lipid droplets (LDs) can store neutral lipids as an energy source when needed
and also regulate the key metabolic processes of intracellular lipid accumulation, which is …

The discovery of perilipin (PLIN) 1 provided a major conceptual shift in the understanding of
adipose tissue lipolysis and generated intense interest in lipid droplet biology research. The …

Abstract Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular
lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to …

The increased prevalence of hyperlipidemia, hypertriglyceridemia, hypercholesterolemia,
and fatty liver disease has provided increasingly negative connotations toward lipids …

Triglycerides are stored within lipid droplets in skeletal muscle and can be hydrolyzed to
produce fatty acids for energy production through β-oxidation and oxidative phosphorylation …

The incidence of obesity and metabolic disease, such as type 2 diabetes mellitus (T2D), is
rising globally. Dietary lipid over supply leads to lipid accumulation at ectopic sites, such as …

The regulation of skeletal muscle lipolysis and fat oxidation is a complex process involving
multiple proteins and enzymes. Emerging work indicates that skeletal muscle PLIN proteins …

The majority of fat in the human body is stored as triacylglycerols in white adipose tissue. In
the obese state, adipose tissue mass expands and excess lipids are stored in non-adipose …