Triggering and resolution of inflammation in NASH

S Schuster, D Cabrera, M Arrese… - Nature reviews …, 2018 - nature.com
Nonalcoholic steatohepatitis (NASH) is considered the progressive form of nonalcoholic fatty
liver disease (NAFLD) and is characterized by liver steatosis, inflammation, hepatocellular …

Lipotoxicity and the gut-liver axis in NASH pathogenesis

F Marra, G Svegliati-Baroni - Journal of hepatology, 2018 - Elsevier
The pathogenesis of non-alcoholic fatty liver disease, particularly the mechanisms whereby
a minority of patients develop a more severe phenotype characterised by hepatocellular …

[HTML][HTML] Oxidative stress and non-alcoholic fatty liver disease: effects of omega-3 fatty acid supplementation

J Yang, M Fernández-Galilea, L Martínez-Fernández… - Nutrients, 2019 - mdpi.com
Aging is a complex phenomenon characterized by the progressive loss of tissue and organ
function. The oxidative-stress theory of aging postulates that age-associated functional …

Bioactive lipid species and metabolic pathways in progression and resolution of nonalcoholic steatohepatitis

G Musso, M Cassader, E Paschetta, R Gambino - Gastroenterology, 2018 - Elsevier
The prevalence of nonalcoholic steatohepatitis (NASH) is increasing worldwide, yet there
are no effective treatments. A decade has passed since the initial lipidomics analyses of liver …

[HTML][HTML] Treating inflammation to combat non-alcoholic fatty liver disease

L Wiering, F Tacke - Journal of Endocrinology, 2023 - joe.bioscientifica.com
Non-alcoholic fatty liver disease (NAFLD) with its more progressive form non-alcoholic
steatohepatitis (NASH) has become the most common chronic liver disease, thereby …

Maresin 1 improves the Treg/Th17 imbalance in rheumatoid arthritis through miR-21

S Jin, H Chen, Y Li, H Zhong, W Sun, J Wang… - Annals of the …, 2018 - ard.bmj.com
Objective Treg/Th17 imbalance plays an important role in rheumatoid arthritis (RA). Maresin
1 (MaR1) prompts inflammation resolution and regulates immune responses. We explored …

The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease

N Perakakis, K Stefanakis, CS Mantzoros - Metabolism, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder, whose
spectrum covers clinical, histological and pathophysiological developments ranging from …

[HTML][HTML] Maresin-1 prevents liver fibrosis by targeting Nrf2 and NF-κB, reducing oxidative stress and inflammation

MJ Rodríguez, M Sabaj, G Tolosa, F Herrera Vielma… - Cells, 2021 - mdpi.com
Liver fibrosis is a complex process characterized by the excessive accumulation of
extracellular matrix (ECM) and an alteration in liver architecture, as a result of most types of …

Lipidomics in pathogenesis, progression and treatment of nonalcoholic steatohepatitis (NASH): Recent advances

G Musso, F Saba, M Cassader, R Gambino - Progress in Lipid Research, 2023 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting up to 30% of the
general adult population. NAFLD encompasses a histological spectrum ranging from pure …

[HTML][HTML] Potential clinical applications of pro-resolving lipids mediators from docosahexaenoic acid

MP Beyer, LA Videla, C Farías, R Valenzuela - Nutrients, 2023 - mdpi.com
Docosahexaenoic acid (C22: 6 n-3, DHA) is the precursor of specialized pro-resolving lipid
mediators (SPMs), such as resolvin, protectin, and maresin families which have been …