EASL Clinical Practice Guidelines on nutrition in chronic liver disease

M Merli, A Berzigotti, S Zelber-Sagi, S Dasarathy… - Journal of …, 2019 - Elsevier
A frequent complication in liver cirrhosis is malnutrition, which is associated with the
progression of liver failure, and with a higher rate of complications including infections …

Sarcopenia from mechanism to diagnosis and treatment in liver disease

S Dasarathy, M Merli - Journal of hepatology, 2016 - Elsevier
Sarcopenia or loss of skeletal muscle mass is the major component of malnutrition and is a
frequent complication in cirrhosis that adversely affects clinical outcomes. These include …

Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases

RR Kalyani, M Corriere, L Ferrucci - The lancet Diabetes & …, 2014 - thelancet.com
The term sarcopenia refers to the loss of muscle mass that occurs with ageing. On the basis
of study results showing that muscle mass is only moderately related to functional outcomes …

[PDF][PDF] Severe muscle depletion in patients on the liver transplant wait list: its prevalence and independent prognostic value

P Tandon, M Ney, I Irwin, MM Ma… - Liver …, 2012 - Wiley Online Library
As detected by cross‐sectional imaging, severe muscle depletion, which is termed
sarcopenia, holds promise for prognostication in patients with cirrhosis. Our aims were to …

Exercise in cirrhosis: translating evidence and experience to practice

P Tandon, KP Ismond, K Riess, A Duarte-Rojo… - Journal of …, 2018 - Elsevier
Physical inactivity, sarcopenia, and frailty are highly prevalent, independent predictors of
morbidity and mortality in patients with cirrhosis. Across a range of chronic diseases …

Ammonia toxicity: from head to toe?

S Dasarathy, RP Mookerjee, V Rackayova… - Metabolic brain …, 2017 - Springer
Ammonia is diffused and transported across all plasma membranes. This entails that
hyperammonemia leads to an increase in ammonia in all organs and tissues. It is known that …

Skeletal muscle depletion is an independent prognostic factor for hepatocellular carcinoma

S Iritani, K Imai, K Takai, T Hanai, T Ideta… - Journal of …, 2015 - Springer
Background Skeletal muscle depletion or sarcopenia has been identified as a poor
prognostic factor for various diseases. The aim of this study is to determine whether muscle …

Eight weeks of exercise training increases aerobic capacity and muscle mass and reduces fatigue in patients with cirrhosis

L Zenith, N Meena, A Ramadi, M Yavari… - Clinical …, 2014 - Elsevier
Background & Aims Patients with cirrhosis have reduced exercise tolerance, measured
objectively as decreased peak exercise oxygen uptake (peak VO 2). Reduced peak VO 2 is …

[PDF][PDF] Muscle mass predicts outcomes following liver transplantation

A DiMartini, RJ Cruz Jr, MA Dew… - Liver …, 2013 - Wiley Online Library
For patients with end‐stage liver disease, commonly used indices of nutritional status (ie,
body weight and body mass index) are often inflated because of fluid overload (ie, ascites …

Randomized pilot study: effects of an exercise programme and leucine supplementation in patients with cirrhosis

E Román, MT Torrades, MJ Nadal, G Cárdenas… - Digestive diseases and …, 2014 - Springer
Background Physical exercise could improve functional limitations, muscle mass, and health-
related quality of life (HRQoL) in patients with cirrhosis. Aim The purpose of this study was to …