Perioperative neurocognitive disorder (PND) is a common surgery outcome affecting up to a
third of the elderly patients, and it is associated with high morbidity and increased risk for …

General anesthetics are a class of drugs that target the central nervous system and are
widely used for various medical procedures. General anesthetics produce many behavioral …

Ferroptosis is a novel type of programmed cell death, which is different from apoptosis and
autophagic cell death. Recently, ferroptosis has been indicated to contribute to the in vitro …

General anesthetic drugs have been associated with various unwanted effects including an
interference with mitochondrial function. We had previously observed increases of lactate …

The use of general anesthetics in modern clinical practice is commonly regarded as safe for
healthy individuals, but exposures at the extreme ends of the age spectrum have been …

Advances in the field of pediatric anesthesiology have enabled the performance of complex
and life-saving procedures with minimal patient discomfort. However, preclinical studies …

The cerebral cortex is widely considered part of the neural substrate of consciousness, but
direct causal evidence is missing. Here, we tested in mice whether optogenetic activation of …

This study quantified eight small-molecule neurotransmitters collected simultaneously from
prefrontal cortex of C57BL/6J mice (n= 23) during wakefulness and during isoflurane …

Since its invention, general anesthesia has been an indispensable component of modern
surgery. While traditionally considered safe and beneficial in many pathological settings …

Purpose Cognitive outcomes in preterm infants may be adversely affected by use of
sedation and anesthetic agents. We investigated the associations between …