Metabolic diseases, featured with dysregulated energy homeostasis, have become major
global health challenges. Patients with metabolic diseases have high probability to manifest …

The WNT/β‐catenin pathway is a master regulator of cardiac development and growth, and
its activity is low in healthy adult hearts. However, even this low activity is essential for …

Objective Obesity is a key risk factor for many secondary chronic illnesses, including type 2
diabetes and cardiovascular disease. Canonical Wnt/β-catenin signaling is established as …

Obesity and type 2 diabetes (T2D) are growing health problems associated with a loss of
insulin sensitivity. Both conditions arise from a long-term energy imbalance, and frequently …

Lipid nanoparticles (LNPs) have recently been used as nanocarriers in drug delivery
systems for nucleic acid drugs. Their practical applications are currently primarily limited to …

Metabolic stress, such as lipotoxicity, affects the DNA methylation profile in pancreatic β-
cells and thus contributes to β-cell failure and the progression of type 2 diabetes (T2D) …

Walnut consumption mostly has a positive implication for cardiovascular health. Walnut diet
effects on the cardiac fatty acid (FA) metabolism of healthy rats and those with fructose diet …

Distinct molecular processes are engaged during histogenesis, and Epithelial to
Mesenchymal Transition (EMT) is one of the key evolutionarily conserved processes that …

Loss of insulin-secreting β-cells in diabetes may be either due to apoptosis or
dedifferentiation of β-cell mass. The ubiquitin-proteasome system comprising E3 ligase and …

目的: 探究M2 型巨噬细胞外泌体包裹miR 鄄374a 对前列腺癌(prostate cancer, PCa)
恶性进展的影响并探讨其分子机制. 方法: 在成功建立M2 型巨噬细胞的基础上 …