Asthma is chronic inflammation of the airways characterized by airway hyper-
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …

Abstract Phosphatidylinositol-3-kinase (PI3K) is a lipid kinase and generates
phosphatidylinositol-3, 4, 5-trisphosphate (PI (3, 4, 5) P3). PI (3, 4, 5) P3 is a second …

Background Ovarian cancer is the most common malignant tumor of the female reproductive
tract. Chemoresistance is a major challenge for current ovarian cancer therapy. However …

Abstract mTOR (mammalian target of rapamycin) has come a long way since its humble
beginnings as a kinase of unknown function. As part of the mTORC1 and mTORC2 …

The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of
rapamycin (mTOR)-dependent pathway is one of the most integral pathways linked to cell …

Background FAT4 functions as a tumor suppressor, and previous findings have
demonstrated that FAT4 can inhibit the epithelial-to-mesenchymal transition (EMT) and the …

Ovarian cancer (OC) is the most lethal gynecological malignancy due to tumor
heterogeneity, the lack of reliable early diagnosis methods and the high incidence of …

The phosphatidyl inositol 3-kinase (PI3K) can be activated by a variety of extracellular
signals and involved in a number of cellular processes including cell proliferation, survival …

Cell division cycle 25 A (Cdc25A), a dual-specificity protein phosphatase, is one of the most
crucial cell cycle regulators, which removes the inhibitory phosphorylation in cyclin …

Extensive evidence implicates activation of the lipid phosphatidylinositide 3-kinase (PI3K)
pathway in the genesis and progression of various human cancers. PI3K inhibitors thus …