The non-essential amino acid serine supports several metabolic processes that are crucial
for the growth and survival of proliferating cells, including protein, amino acid and …

Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …

Many tumour cells show dependence on exogenous serine and dietary serine and glycine
starvation can inhibit the growth of these cancers and extend survival in mice. However …

Serine/glycine biosynthesis and one‑carbon metabolism are crucial in sustaining cancer cell
survival and rapid proliferation, and of high clinical relevance. Excessive activation of …

While metabolic reprogramming of cancer cells has long been considered from the
standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis …

Cancer cells reprogramme their metabolism to support unrestrained proliferation and
survival in nutrient-poor conditions. Whereas non-transformed cells often have lower …

Serine metabolism is frequently dysregulated in cancers; however, the benefit that this
confers to tumors remains controversial. In many cases, extracellular serine alone is …

Crosstalk between cellular metabolism and the epigenome regulates epigenetic and
metabolic homeostasis and normal cell behavior. Changes in cancer cell metabolism can …

Tumors exhibit altered metabolism compared to normal tissues. Many cancers upregulate
expression of serine synthesis pathway enzymes, and some tumors exhibit copy-number …

Autophagy is a mechanism that enables cells to maintain cellular homeostasis by removing
damaged materials and mobilizing energy reserves in conditions of starvation. Although …