During the past few decades, the science of toxicology has been undergoing a
transformation from observational to predictive science. New approach methodologies …

New approach methodologies (NAMs) that make use of in vitro screening and in silico
approaches to inform chemical evaluations rely on in vitro toxicokinetic (TK) data to translate …

Mucoadhesive formulations capable of situ gelation are promising for improving ocular drug
delivery. Here we investigated two types of nanogels based on anionic glycosaminoglycans …

The goal of the present study was to assess the predictive performance of a minimal generic
rat physiologically based kinetic (PBK) model based on in vitro and in silico input data to …

In our previous study, we observed that androgen deprivation therapy (ADT) may induce a
compensatory increase in MAPK or JNK signaling. Here, we tested the effects of the MEK …

Predicting human hepatic clearance remains a fundamental challenge in both
pharmaceutical drug development and toxicological assessments of environmental …

In vitro cell-based toxicity testing methods generate large amounts of data informative for risk-
based evaluations. To allow extrapolation of the quantitative outputs from cell-based tests to …

In biological systems (cell culture media, cells, body fluids), drugs/toxicants are usually not
freely dissolved but partially bound to biomolecules; only a fraction of the chemical is …

The evaluation of exposure to multiple contaminants in a mixture presents a number of
challenges. For example, the characterization of chemical metabolism in a mixture setting …

During the past few decades, the science of toxicology has been undergoing a
transformation from observational to predictive science. New approach methodologies …